INT30138

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Context Info
Confidence 0.16
First Reported 1985
Last Reported 1985
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 1.69

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peptidase activity (TPP1) mitochondrion (TPP1) cell death (TPP1)
lipid metabolic process (TPP1) lysosome (TPP1)
Anatomy Link Frequency
CLN 2
TPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 22 100.00 Very High Very High Very High
agonist 2 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 6 97.96 Very High Very High Very High
Hypotension 2 96.16 Very High Very High Very High
Pressure Volume 2 Under Development 2 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that NIF and CLN do not interact negatively on blood pressure control in essential hypertensive subjects.
CLN Neg (negatively) Binding (interact) of in CLN associated with hypertension and clonidine
1) Confidence 0.16 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 2856710 Disease Relevance 0.40 Pain Relevance 0.94
In order to evaluate possible negative interactions between NIF and CLN in man during chronic treatment with these drugs, 12 patients with mild to moderate uncomplicated essential hypertension received either NIF (20 mg twice daily), CLN (0.25 mg once daily), the two drugs together at the same doses, or their matched placebos for a 2-week period each.
CLN Neg (negative) Binding (interactions) of in CLN associated with hypertension and clonidine
2) Confidence 0.12 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 2856710 Disease Relevance 0.34 Pain Relevance 0.76

General Comments

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