INT301402

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) extracellular space (Enpp2) extracellular region (Enpp2)
plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Anatomy Link Frequency
osteoclast 1
Enpp2 (Mus musculus)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 89.80 High High
Potency 5 50.04 Quite High
antagonist 16 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
Neuropathic pain 9 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 92 90.80 High High
Osteoporosis 7 89.40 High High
Skin Cancer 5 86.48 High High
Breast Cancer 49 86.24 High High
Embryonic Lethality 4 62.16 Quite High
Metastasis 67 50.00 Quite Low
Targeted Disruption 19 35.60 Quite Low
Exencephaly /

Neural Tube Defects

1 31.84 Quite Low
Hypoxia 1 17.04 Low Low
Ovarian Cancer 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our results suggested that LPA generated by autotaxin in the presence of serum might control directly osteoclast differentiation.
autotaxin Positive_regulation (generated) of LPA in osteoclast
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.32 Pain Relevance 0.07
In extracellular biological fluids, LPA production is linked to ATX, which is a lysophospholipase D that cleaves the headgroup from lysophospholipids to generate LPA.
lysophospholipase D Positive_regulation (generate) of LPA
2) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.23 Pain Relevance 0

General Comments

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