INT301408

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0.03

cell differentiation (Twist1) generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) nucleus (Twist1) plasma membrane (Enpp1) DNA binding (Twist1)

Enpp1 (Mus musculus) Twist1 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 1 50.80 Potency 2 5.00 palliative 1 5.00 cytokine 1 5.00 Neuropathic pain 1 5.00 Inflammation 1 5.00 Pain 1 5.00 rheumatoid arthritis 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 46 66.80 Metastasis 57 54.28 Cancer 68 50.00 Advanced Or Metastatic Breast Cancer 1 38.04 Osteoporosis 4 33.36 Targeted Disruption 4 16.00 Hepatocellular Cancer 1 13.36 Thyroid Neoplasm 1 12.12 Skin Cancer 2 9.92 Lung Cancer 2 9.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As expected, we observed that in the absence of doxycycline only MDA-B02-ATX clones acquired a lysoPLD activity (Figure 1B), whereas both MDA-B02-ATX and MDA-B02-NPP1 clones had an increased PDE activity, as compared to parental cells (Figure 1B).

Positive_regulation (increased) of NPP1 Binding (activity) of PDE

1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

This test has worked.