INT301414

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) extracellular space (Enpp2) extracellular region (Enpp2)
nucleus (Twist1) DNA binding (Twist1) transcription factor binding (Twist1)
Enpp2 (Mus musculus)
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2 70.08 Quite High
Neuropathic pain 2 67.92 Quite High
antagonist 2 50.80 Quite High
Pain 2 41.88 Quite Low
Potency 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 88.08 High High
Metastasis 114 85.56 High High
Cancer 136 82.68 Quite High
Rheumatoid Arthritis 2 70.08 Quite High
Neuropathic Pain 2 67.92 Quite High
Breast Cancer 92 66.80 Quite High
Chronic Hepatitis 2 66.08 Quite High
Obesity 2 61.20 Quite High
Skin Cancer 4 52.16 Quite High
Hypercalcemia 12 46.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, we observed that in the absence of doxycycline only MDA-B02-ATX clones acquired a lysoPLD activity (Figure 1B), whereas both MDA-B02-ATX and MDA-B02-NPP1 clones had an increased PDE activity, as compared to parental cells (Figure 1B).
MDA-B02-ATX Binding (activity) of PDE
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.18 Pain Relevance 0.03
The biological significance of PDE and lysoPLD activities in autotaxin functions remains to be determined.
autotaxin Binding (activities) of PDE
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.08 Pain Relevance 0.10

General Comments

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