INT301455

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Smyd2) methyltransferase activity (Smyd2) nucleus (Smyd2)
cytoplasm (Smyd2)
Anatomy Link Frequency
heart 2
cardiomyocytes 1
Smyd2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 3 24.76 Low Low
imagery 18 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 6 90.48 High High
Apoptosis 3 90.00 High High
Stress 9 85.28 High High
Myocardial Infarction 3 84.08 Quite High
Dilated Cardiomyopathy 3 83.24 Quite High
Hypoxia 3 82.24 Quite High
Cancer 6 67.40 Quite High
Stroke 3 36.60 Quite Low
Cardiovascular Disorder Under Development 3 24.76 Low Low
Targeted Disruption 21 8.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of deregulated genes in Smyd2 cKO hearts displayed reduced expression.
Regulation (deregulated) of Smyd2 cKO in hearts
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0
Given the importance of understanding the precise mechanisms of p53 regulation in vivo, our Smyd2 cKO mice will provide a useful tool for gathering such information in the heart as well as other organs.
Regulation (regulation) of Smyd2 cKO in heart
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.66 Pain Relevance 0
Taken together, the data indicate that Smyd1 and Smyd2 are the only Smyd-family members observed to be preferentially expressed in cardiomyocytes, and their levels are markedly regulated during cardiac development.


Regulation (regulated) of Smyd2 in cardiomyocytes
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0

General Comments

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