INT301467

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smyd3, Helz) methyltransferase activity (Smyd3) helicase activity (Helz)
cellular_component (Smyd3) cytoplasm (Smyd3)
Smyd3 (Mus musculus)
Helz (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 80.56 Quite High
Stress 6 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Embryonic Lethality 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we provide evidence for a potential role of Smyd2 in the transcriptional regulation of genes associated with translation and reveal that Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ.



Smyd3 Binding (interacts) of HELZ
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2840034 Disease Relevance 0.08 Pain Relevance 0
In addition to catalyzing H3K4 HMTase activity, Smyd3 may act as a direct transcriptional regulator via a ternary association with RNA Polymerase II and the RNA helicase, HELZ [19].
Smyd3 Binding (association) of HELZ
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0

General Comments

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