INT301468

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Smyd2, Trp53) cytosol (Smyd2, Trp53) nucleus (Smyd2, Trp53)
nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
Smyd2 (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 96.04 Very High Very High Very High
Dilated Cardiomyopathy 1 79.92 Quite High
Apoptosis 1 65.36 Quite High
Necrosis 2 64.32 Quite High
Stress 3 27.28 Quite Low
Myocardial Infarction 1 26.08 Quite Low
Hypoxia 1 24.24 Low Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we did not specifically address the functional consequence of Smyd2 deficiency for p53 activity in vivo, one might have expected a pronounced phenotype, at least in adult Smyd2 cKO animals.
Smyd2 Negative_regulation (deficiency) of p53
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.31 Pain Relevance 0

General Comments

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