INT301474

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Helz, Smyd2) cytosol (Smyd2) methyltransferase activity (Smyd2)
helicase activity (Helz) cytoplasm (Smyd2)
Helz (Mus musculus)
Smyd2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 81.28 Quite High
Cancer 4 56.32 Quite High
Stress 6 33.36 Quite Low
Hypertrophy 4 27.88 Quite Low
Dilated Cardiomyopathy 2 26.00 Quite Low
Apoptosis 2 11.44 Low Low
Necrosis 4 10.40 Low Low
Embryonic Lethality 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we provide evidence for a potential role of Smyd2 in the transcriptional regulation of genes associated with translation and reveal that Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ.



HELZ Binding (interacts) of Smyd2
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2840034 Disease Relevance 0.08 Pain Relevance 0
The finding that Smyd2 is capable of interacting with RNA Polymerase II as well as the RNA helicase, HELZ, suggests that Smyd2 might share functional similarities with Smyd3 [19].
HELZ Binding (interacting) of Smyd2
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.06 Pain Relevance 0

General Comments

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