INT301525

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4a14) endoplasmic reticulum (Cyp4a14)
Cyp4a14 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 33 59.52 Quite High
antagonist 3 46.60 Quite Low
Inflammation 48 44.68 Quite Low
chemokine 12 29.52 Quite Low
cytokine 6 19.16 Low Low
fibrosis 33 5.00 Very Low Very Low Very Low
alcohol 15 5.00 Very Low Very Low Very Low
Bile 15 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 36 97.80 Very High Very High Very High
Targeted Disruption 21 94.88 High High
Nash(non-alcoholic Steatohepatitis) 81 92.08 High High
Fatty Liver 189 91.76 High High
Liver Disease 54 57.04 Quite High
Iron Overload 3 49.92 Quite Low
Autoimmune Hepatitis 3 49.24 Quite Low
Cholangitis 3 48.36 Quite Low
Biliary Liver Cirrhosis 6 47.00 Quite Low
Metabolic Syndrome 69 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microsomal oxidation of fatty acids, catalyzed by cytochrome CYP2E1, CYP4A10, CYP4A12, and CYP4A14, which are induced in mouse models of steatosis and steatohepatitis, is a potent source of ROS through uncoupling of their catalytic cycles.
Positive_regulation (induced) of CYP4A14
1) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.16 Pain Relevance 0
The importance of induction of CYP4A genes in hepatic steatosis and steatohepatitis was revealed in Cyp2e1-null mice that developed severe steatohepatitis with a pronounced increase in CYP4A10 and CYP4A14 associated with increased accumulation of lipid peroxides.
Positive_regulation (increase) of CYP4A14
2) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.46 Pain Relevance 0.03
A dramatic induction of both the mouse CYP4A10 and CYP4A14 genes is seen in Cyp2e1-null mice and likely accounts for the increased ROS that induce lipid peroxidation [103, 104].
Positive_regulation (induction) of CYP4A14
3) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.23 Pain Relevance 0

General Comments

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