INT301526

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
G6pc (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 84.48 Quite High
cytokine 4 71.68 Quite High
fibrosis 22 64.08 Quite High
Inflammation 32 60.68 Quite High
agonist 22 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 6 95.52 Very High Very High Very High
Diabetes Mellitus 34 92.72 High High
Metabolic Syndrome 46 91.92 High High
Obesity 22 87.08 High High
Insulin Resistance 50 86.64 High High
Stress 24 72.56 Quite High
Hepatocellular Cancer 10 70.04 Quite High
Liver Failure 2 68.44 Quite High
Hepatic Encephalopathy 2 67.68 Quite High
Cirrhosis 16 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both IRS-1 and IRS-2 inhibit the transcription factor FOXO-mediated gene transcription of PEPCK, G6Pase, and PGC-1?
Transcription (transcription) of G6Pase
1) Confidence 0.23 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.64 Pain Relevance 0.08
FFAs increase the transcription of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6Pase), peroxisome proliferator-activated receptor coactivator ?
Transcription (transcription) of G6Pase
2) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.33 Pain Relevance 0.14

General Comments

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