INT30153

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.72
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
plasma 1
smooth muscle 1
brain 1
osteoclast 1
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 4 100.00 Very High Very High Very High
Endogenous opioid 3 100.00 Very High Very High Very High
corticosteroid 3 100.00 Very High Very High Very High
cytokine 8 99.80 Very High Very High Very High
opiate 2 99.70 Very High Very High Very High
Fibrositis 77 99.38 Very High Very High Very High
Inflammation 8 99.08 Very High Very High Very High
antagonist 20 97.60 Very High Very High Very High
Opioid 1 91.20 High High
Somatostatin 2 87.28 High High
Disease Link Frequency Relevance Heat
Stress 21 100.00 Very High Very High Very High
Fibromyalgia 77 99.38 Very High Very High Very High
Breast Cancer 9 99.28 Very High Very High Very High
INFLAMMATION 10 99.08 Very High Very High Very High
Cancer 134 98.80 Very High Very High Very High
Hypercalcemia 65 97.32 Very High Very High Very High
Adult T-cell Leukemia-lymphoma 34 96.60 Very High Very High Very High
Metastasis 70 94.80 High High
Bone Cancer 7 93.40 High High
Osteoporosis 37 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTHrP levels are not affected by bisphosphonate therapy[8] and the management of the refractory hypercalcaemia of ATLL is limited.
Neg (not) Regulation (affected) of PTHrP associated with hypercalcemia and adult t-cell leukemia-lymphoma
1) Confidence 0.58 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.50 Pain Relevance 0.16
RESULTS: Total and ionized calcium, phosphate, creatinine, PTHrP and calcitonin levels were not altered significantly after 24 hours or 28 days in any of the subjects, when compared to baseline.
Neg (not) Regulation (altered) of PTHrP
2) Confidence 0.57 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 7889637 Disease Relevance 0.29 Pain Relevance 0
PURPOSE: Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care.
Regulation (effects) of antiestrogen hormone associated with breast cancer
3) Confidence 0.27 Published 2010 Journal J. Clin. Oncol. Section Abstract Doc Link 20038728 Disease Relevance 0.27 Pain Relevance 0.11
High levels of inflammatory cytokines also potentiate the hypercalcaemic effect of PTHrP, and stimulate further PTHrP production.
Regulation (effect) of PTHrP associated with inflammation and cytokine
4) Confidence 0.26 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.37 Pain Relevance 0.15
Mechanically transduced signals have been shown to regulate PTHrP expression and secretion in a variety of smooth muscle beds [6].
Regulation (regulate) of PTHrP in smooth muscle
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.24 Pain Relevance 0.05
There were no changes in serum phosphorus, PTH, PTHrP, 1,25-(OH)2 vitamin D concentrations or in the urinary Ca/Cr and urinary phosphorus/Cr ratios after seven days of r-hPRL and placebo treatment (Table 1).
Neg (no) Regulation (changes) of PTHrP
6) Confidence 0.19 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.35 Pain Relevance 0.06
The concentrations of CPPD and PLP in the supplemented medium were the same in the different test samples as the same batch of supplemented medium was used.


Regulation (concentrations) of PLP
7) Confidence 0.13 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.06 Pain Relevance 0
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Regulation (responsible) of parathyroid hormone-related protein in osteoclast associated with cancer and cytokine
8) Confidence 0.12 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.69 Pain Relevance 0.19
We observed the acute effects of Qigong training on the levels of human endogenous opioid peptides, such as beta-endorphin, and other stress hormones [adrenocorticotrophic hormone (ACTH), cortisol, and dehydroepiandrosterone-sulfate (DHEA-S)] in a group of ChunDoSunBup Qigong trainees.
Regulation (effects) of adrenocorticotrophic hormone associated with stress and endogenous opioid
9) Confidence 0.04 Published 1996 Journal Am. J. Chin. Med. Section Abstract Doc Link 8874677 Disease Relevance 0.23 Pain Relevance 0.10
The effects of a single bolus dose of etomidate 0.3 mg kg-1 or thiopentone 5 mg kg-1, on the synthesis of corticosteroid hormones and adrenocorticotrophic hormone (ACTH), were compared for 24 h in 12 patients, undergoing minor surgery under general anaesthesia.
Regulation (effects) of adrenocorticotrophic hormone associated with corticosteroid
10) Confidence 0.03 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 2982387 Disease Relevance 0 Pain Relevance 0.18
The effects of iv stimulation with clonidine on plasma levels of beta-lipotropin (beta-LPH), beta-endorphin (beta-EP), cortisol, growth hormone (GH) and adrenocorticotrophic hormone (ACTH) were tested in a group of 10 healthy volunteers and in 8 heroin abusers.
Regulation (effects) of adrenocorticotrophic hormone in plasma associated with clonidine
11) Confidence 0.02 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857510 Disease Relevance 0 Pain Relevance 0.17
It is concluded that narcotic antagonist inhibition of endogenous opioid action provides further evidence supporting a role for the brain opiates in the normal regulation of neurohypophysial hormone release in man.
Regulation (regulation) of neurohypophysial hormone in brain associated with antagonist, endogenous opioid and opiate
12) Confidence 0.02 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6103008 Disease Relevance 0 Pain Relevance 0.49
Previous studies suggested the existence of perturbation of the HPA axis in fibromyalgia [24,25], and a hyper-reactive response of adrenocorticotrophic hormone and GH to various stimuli was detected, whereas in the cortisol response, a decrease occurred [26-28].
Regulation (response) of adrenocorticotrophic hormone associated with fibrositis
13) Confidence 0.00 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 0.63 Pain Relevance 0.21

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