INT301533

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.32
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fabp1) cytosol (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
liver 4
fat 2
Caco-2 2
Fabp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 85.60 High High
fibrosis 118 72.64 Quite High
Inflammation 43 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 43 99.16 Very High Very High Very High
Body Weight 10 92.96 High High
Repression 4 91.44 High High
Metabolic Syndrome 46 90.08 High High
Disorder Of Lipid Metabolism 40 72.68 Quite High
Cystic Fibrosis 96 72.64 Quite High
Fatty Liver 126 57.40 Quite High
Insulin Resistance 53 49.20 Quite Low
Obesity 22 35.08 Quite Low
Disease 46 29.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the liver, expression of cyp4a10, cyp4a14 and fatty acid binding protein 1 (FABP1) was induced by 0.04% vaticanol C in the wild-type, but not in the knockout mice (Figure 3A).
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of FABP1 in liver associated with targeted disruption
1) Confidence 0.37 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.38 Pain Relevance 0.08
In the liver, expression of cyp4a10, cyp4a14 and fatty acid binding protein 1 (FABP1) was induced by 0.04% vaticanol C in the wild-type, but not in the knockout mice (Figure 3A).
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of fatty acid binding protein 1 in liver associated with targeted disruption
2) Confidence 0.37 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.38 Pain Relevance 0.08
A high fat diet potently increases the expression of L-FABP [42] and microsomal triglyceride transfer protein (MTP) via PPAR?
Positive_regulation (via) of Gene_expression (expression) of L-FABP in fat
3) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.29 Pain Relevance 0
CD36/FAT is closely correlated with the degree of mitochondrial fatty acid oxidation, while L-FABP, also known as the mitochondrial aspartate aminotransferase (mAST), may have distinct functions at different subcellular sites.
Positive_regulation (aspartate aminotransferase) of Gene_expression (aspartate aminotransferase) of L-FABP
4) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.05 Pain Relevance 0
However, apart from increasing its buffer capacity through upregulation of L-FABP expression, Caco-2/15 cells appear to challenge the FA overload by efficiently channeling FAs toward the lipoprotein secretory pathways, i.e. the endoplasmic reticulum.
Positive_regulation (upregulation) of Gene_expression (expression) of L-FABP in Caco-2
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
Conversely, the protein expression of L-FABP that participates mainly in intracellular FA trafficking was increased by almost 2-fold in CFTR knockdown cells (Figure 6B).


Positive_regulation (increased) of Gene_expression (expression) of L-FABP
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
These findings are further substantiated by the enhanced L-FABP expression and a trend toward increased expression of the FA membrane transporter, FAT/CD36.
Positive_regulation (enhanced) of Gene_expression (expression) of L-FABP
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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