INT30154

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.18
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (DBI) transport (DBI)
Anatomy Link Frequency
plasma 2
DBI (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 8 99.98 Very High Very High Very High
opiate 2 97.80 Very High Very High Very High
Opioid 2 55.28 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 8 99.84 Very High Very High Very High
Obesity 20 91.80 High High
Body Weight 2 65.96 Quite High
Hyperphagia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normal prepubertal subjects, the circadian rhythms of beta EP and beta LPH secretion and release induced by hypoglycemia suggest the presence of a well developed neuroendocrine control of proopiomelanocortin-related peptide secretion.
Positive_regulation (induced) of Localization (release) of EP associated with hypoglycemia
1) Confidence 0.33 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 1.09 Pain Relevance 0.06
In normal prepubertal subjects, the circadian rhythms of beta EP and beta LPH secretion and release induced by hypoglycemia suggest the presence of a well developed neuroendocrine control of proopiomelanocortin-related peptide secretion.
Positive_regulation (induced) of Localization (secretion) of EP associated with hypoglycemia
2) Confidence 0.33 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 1.09 Pain Relevance 0.06
In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection.
Positive_regulation (induced) of Localization (release) of beta-EP associated with clonidine
3) Confidence 0.07 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857510 Disease Relevance 0 Pain Relevance 0.24
Clonidine-induced release of plasma beta-EP may be of importance with regard to its therapeutic effects in detoxification.
Positive_regulation (induced) of Localization (release) of beta-EP in plasma associated with clonidine
4) Confidence 0.07 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857510 Disease Relevance 0 Pain Relevance 0.34

General Comments

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