INT301549

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.27
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4a10) endoplasmic reticulum (Cyp4a10)
Anatomy Link Frequency
hepatocytes 1
fat 1
Cyp4a10 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 77 89.68 High High
Inflammation 112 73.80 Quite High
chemokine 28 58.64 Quite High
cytokine 14 48.28 Quite Low
Kinase C 21 16.72 Low Low
fibrosis 77 5.00 Very Low Very Low Very Low
alcohol 35 5.00 Very Low Very Low Very Low
Bile 35 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
fluoxetine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 84 98.04 Very High Very High Very High
Repression 14 97.72 Very High Very High Very High
Hyperoxia 7 96.40 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 189 90.20 High High
Fatty Liver 441 90.04 High High
Liver Disease 126 86.16 High High
Metabolic Syndrome 161 80.64 Quite High
Iron Overload 7 79.04 Quite High
Autoimmune Hepatitis 7 78.36 Quite High
Cholangitis 7 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential regulation of the CYP4A and CYP4F genes by peroxisome proliferators, during fasting and by high fat diets indicates that these P450s may have distinct roles in lipid metabolism during the fasting and feeding cycles, and that different nuclear transcription factors regulate the expression of these genes (Figure 1).
Regulation (regulation) of CYP4A in fat
1) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.95 Pain Relevance 0.10
The modest 2-fold induction of the CYP4A11 gene by peroxisome proliferators in primary human hepatocytes compared with the 30–70 fold induction of the mouse CYP4A genes indicates a species difference between rodents and humans with respect to regulation of the CYP4A genes by peroxisome proliferators [150].
Regulation (regulation) of CYP4A in hepatocytes
2) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.70 Pain Relevance 0.08
To resolve this issue and to further define the role of CYP4A genes in production of ROS during hepatic steatosis, mouse models overexpressing CYP4A10 and CYP4A14 will be needed to determine if excessive fatty acid induces uncoupling of the P450 catalytic cycle and generation of ROS during the progression of NAFLD to NASH.
Regulation (role) of CYP4A associated with fatty liver and nash(non-alcoholic steatohepatitis)
3) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.36 Pain Relevance 0.13
In contrast to the extensive data on the role of rodent CYP4A gene in animal models of steatosis and steatohepatitis, little is known about how the human CYP4A11 gene is controlled by PPAR?
Regulation (rodent) of CYP4A
4) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.54 Pain Relevance 0.09
In contrast to the extensive data on the role of rodent CYP4A gene in animal models of steatosis and steatohepatitis, little is known about how the human CYP4A11 gene is controlled by PPAR?
Regulation (role) of CYP4A
5) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.54 Pain Relevance 0.09
This scenario is highly likely in the regulation of CYP4A and CYP4F genes since peroxisome proliferators (PP) activate PPAR?
Spec (likely) Regulation (regulation) of CYP4A
6) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.09 Pain Relevance 0
For instance, the differential regulation of the CYP4A and CYP4F genes may be determined by cross-talk between PPAR?
Regulation (regulation) of CYP4A
7) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox