INT301564

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 1.55
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4f18) endoplasmic reticulum (Cyp4f18)
Anatomy Link Frequency
cardiomyocytes 4
liver 3
heart 3
kidney 2
skin 1
Cyp4f18 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 17 96.04 Very High Very High Very High
Inflammation 102 94.44 High High
ischemia 11 91.28 High High
Bioavailability 2 60.00 Quite High
Inflammatory response 3 47.20 Quite Low
alcohol 15 31.44 Quite Low
Calcium channel 18 13.44 Low Low
Angina 9 7.76 Low Low
fibrosis 45 5.00 Very Low Very Low Very Low
agonist 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 99 94.44 High High
Reperfusion Injury 9 92.04 High High
Cv Unclassified Under Development 11 91.28 High High
Chronic Renal Failure 20 88.04 High High
Myocardial Infarction 81 86.88 High High
Increased Venous Pressure Under Development 21 79.56 Quite High
Cardiovascular Disease 27 68.24 Quite High
Disease Progression 19 59.32 Quite High
Albuminuria 20 50.00 Quite Low
Starvation 24 47.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
Neg (not) Gene_expression (expressed) of CYP4F3A in skin
1) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06
The CYP450 expression in the kidney is high and EETs promote renal sodium excretion [1], [2].
Gene_expression (expression) of CYP450 in kidney
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.18 Pain Relevance 0.12
In order to determine whether changes in EET production underlie the effects observed, the renal expression of sPLA2, sEH and CYP450 enzymes was determined.
Spec (determined) Gene_expression (expression) of CYP450
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.15 Pain Relevance 0.05
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
Neg (not) Gene_expression (expressed) of CYP4F3A in liver
4) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
Neg (not) Gene_expression (expressed) of CYP4F3A in kidney
5) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06
Several drugs exert their pharmacological effects on the heart and are prone to being metabolized by CYP450 isozymes expressed in cardiac tissues.
Gene_expression (expressed) of CYP450 in heart
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.52 Pain Relevance 0.07
Indeed, recent reports have demonstrated the presence of CYP450 gene products in a cardiomyoblast cell line [2], in cultured rat cardiomyocytes [3], in the heart of several animal species such as rat [4], [5], rabbit [6], fish [7], sheep [8] and pig [9] and more importantly, in samples of a few explanted human hearts [10], [11], [12].
Gene_expression (products) of CYP450 in heart
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0
These results are in line with observations by DeLoziers et al., although they did not control for false positive results due to lipofuscine.[12] In our study, the presence of CYP450 proteins was clearly demonstrated inside cardiomyocytes away from nucleus and detritus residues of proteins accumulated by lipofuscine.
Gene_expression (presence) of CYP450 in cardiomyocytes
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.06 Pain Relevance 0
The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart.


Gene_expression (expressed) of CYP450 in heart
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001885 Disease Relevance 0.09 Pain Relevance 0
Although CYP450 enzymes are mainly expressed in the liver, most extrahepatic tissues express CYP450 isozymes to varying degrees.
Gene_expression (express) of CYP450 in liver
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0
Results obtained by immunohistochemistry analyses demonstrate that CYP450 proteins such as CYP2J2 and CYP2Cs are expressed in human cardiomyocytes.
Gene_expression (expressed) of CYP450 in cardiomyocytes
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.07 Pain Relevance 0
Although CYP450 enzymes are mainly expressed in the liver, most extrahepatic tissues express CYP450 isozymes to varying degrees.
Gene_expression (expressed) of CYP450 in liver
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0
Detection of CYP450 proteins in human cardiac myocytes
Gene_expression (Detection) of CYP450 in cardiac myocytes
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.06 Pain Relevance 0
Immunohistochemical studies were performed to confirm CYP450 expression in human cardiomyocytes.
Gene_expression (expression) of CYP450 in cardiomyocytes
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.06 Pain Relevance 0

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