INT301590

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.12
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fabp1) cytosol (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
nucleus 3
fibroblasts 1
Fabp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 83 73.96 Quite High
fibrosis 87 59.32 Quite High
Kinase C 15 38.20 Quite Low
agonist 55 5.00 Very Low Very Low Very Low
alcohol 25 5.00 Very Low Very Low Very Low
Bile 25 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 22 96.36 Very High Very High Very High
Fatty Liver 315 86.48 High High
Liver Disease 90 77.44 Quite High
INFLAMMATION 78 73.96 Quite High
Diabetes Mellitus 86 73.24 Quite High
Syndrome 10 71.80 Quite High
Adrenoleukodystrophy 10 70.92 Quite High
Disease 67 70.04 Quite High
Metabolic Syndrome 115 69.56 Quite High
Nash(non-alcoholic Steatohepatitis) 135 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of LCFA uptake and importation into the nucleus has recently been shown to be mediated by L-FABP, which binds polyunsaturated LCFAs with a greater affinity than saturated LCFAs and associates with PPAR?
L-FABP Binding (binds) of in nucleus
1) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.49 Pain Relevance 0.04
is able to be activated by selective fatty acids through interaction with L-FABP or ACBP.
L-FABP Binding (interaction) of
2) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.98 Pain Relevance 0
Recent studies have shown that L-FABP also functions to shuttle lipids to the nucleus to allow them to directly interact with PPAR?
L-FABP Binding (functions) of in nucleus
3) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
The mechanism of LCFA uptake and importation into the nucleus has recently been shown to be mediated by L-FABP, which binds polyunsaturated LCFAs with a greater affinity than saturated LCFAs and associates with PPAR?
L-FABP Binding (associates) of in nucleus
4) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.49 Pain Relevance 0.04
In contrast, dietary PUFAs associated with L-FABP would activate PPAR?
L-FABP Binding (associated) of
5) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.10 Pain Relevance 0
Moreover, L-FABP disruption was associated with the stimulation of FA uptake both in fibroblasts and in l-fabp null mice [42], [43].
L-FABP Binding (associated) of in fibroblasts
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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