INT301598

Context Info Confidence 0.41 First Reported 2009 Last Reported 2009 Negated 3 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.36 Pain Relevance 0.18

small molecule metabolic process (CYP4F2) endoplasmic reticulum (CYP4F2)

Anatomy Link Frequency liver 1 skin 1 kidney 1 CYP4F2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 48 64.72 Inflammatory response 3 47.20 alcohol 15 31.44 fibrosis 33 5.00 agonist 33 5.00 Bile 15 5.00 chemokine 12 5.00 Kinase C 9 5.00 cytokine 6 5.00 methotrexate 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 45 64.72 Starvation 24 45.32 Toxicity 15 12.32 Fatty Liver 189 5.00 Nash(non-alcoholic Steatohepatitis) 81 5.00 Insulin Resistance 75 5.00 Metabolic Syndrome 69 5.00 Liver Disease 54 5.00 Diabetes Mellitus 51 5.00 Disease 39 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.

Neg (not) Gene_expression (expressed) of CYP4F2 in skin

1) Confidence 0.41 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06

The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.

Neg (not) Gene_expression (expressed) of CYP4F2 in liver

2) Confidence 0.14 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06

The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.

Neg (not) Gene_expression (expressed) of CYP4F2 in kidney

3) Confidence 0.14 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

This test has worked.