INT30160

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 1.92
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRA2B) cell-cell signaling (ADRA2B) signal transducer activity (ADRA2B)
Anatomy Link Frequency
brain 1
SK-N-SH 1
ADRA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 60 100.00 Very High Very High Very High
noradrenaline 6 99.28 Very High Very High Very High
opioid receptor 40 98.84 Very High Very High Very High
Opioid 17 98.40 Very High Very High Very High
antagonist 26 98.16 Very High Very High Very High
Clonidine 15 97.32 Very High Very High Very High
bradykinin 8 96.08 Very High Very High Very High
Neurotransmitter 4 95.08 Very High Very High Very High
Inflammation 60 94.04 High High
Morphine 5 89.32 High High
Disease Link Frequency Relevance Heat
Apoptosis 1 96.00 Very High Very High Very High
Neuroblastoma 5 95.68 Very High Very High Very High
INFLAMMATION 55 94.04 High High
Bordatella Infection 9 92.28 High High
Coagulation Disorder 1 86.40 High High
Gastroesophageal Reflux Disease 45 83.24 Quite High
Colitis 3 80.56 Quite High
Glioma 1 78.76 Quite High
Inflammatory Bowel Disease 1 77.60 Quite High
Esophageal Disease 20 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No evidence of alpha-adrenergic receptor mediation of adenylate cyclase was noted with the alpha 2-specific agonist, clonidine.
Positive_regulation (mediation) of alpha-adrenergic receptor associated with agonist and clonidine
1) Confidence 0.29 Published 1983 Journal J. Invest. Dermatol. Section Abstract Doc Link 6304198 Disease Relevance 0 Pain Relevance 0.48
In contrast, for the alpha 2B-C2 subtype the agonists stimulated both basal and forskolin stimulated cAMP production.
Positive_regulation (stimulated) of alpha 2B-C2 associated with agonist
2) Confidence 0.17 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.28
In contrast, for the alpha 2B-C2 subtype the agonists stimulated both basal and forskolin stimulated cAMP production.
Positive_regulation (stimulated) of alpha 2B-C2 associated with agonist
3) Confidence 0.17 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.28
We measured agonist-stimulated binding of the stable GTP-analog guanosine-5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) as a functional assay to monitor G-protein activation by recombinant human alpha2-adrenoceptor subtypes alpha2A, alpha2B and alpha2C. (-)-Noradrenaline was a full agonist in all receptors.
Positive_regulation (activation) of alpha2B associated with noradrenaline and agonist
4) Confidence 0.10 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9760042 Disease Relevance 0.06 Pain Relevance 0.51
These studies also found evidence for secretin, prostacyclin, opioid and alpha2-adrenergic receptors In support of this we found significantly high levels of mRNA for Ptgir1, Ptger1, Ptger3, Ptger4, Oprd1, Oprl1 and Adra2b.
Positive_regulation (levels) of Adra2b associated with opioid
5) Confidence 0.06 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.14
U73122 treatment also blocked functional responses of m4 muscarinic receptor and alpha2-adrenoceptor in NG108-15 cells and three opioid receptors (mu, delta and opioid receptor-like receptor (ORL1)) in human neuroblastoma SK-N-SH cells. 1-[6-((17Beta-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2, 5-pyrrolidinedione (U73343), an inactive analog of U73122, did not show any effect, which suggests that the blockade by U73122 of Gi-coupled receptor-mediated signaling is probably mediated through inhibition of phospholipase C, although a possible direct modification of G proteins can not be excluded.
Positive_regulation (responses) of alpha2-adrenoceptor in SK-N-SH associated with neuroblastoma and opioid receptor
6) Confidence 0.06 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.19
PAR is a seven transmembrane trimer-G-protein-coupled receptor that is activated by a specific protease.
Positive_regulation (activated) of trimer-G-protein-coupled receptor
7) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.84 Pain Relevance 0.11
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Positive_regulation (Actions) of alpha2 adrenoceptor associated with antagonist and agonist
8) Confidence 0.03 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.27
Administration of the dopaminergic agonists bromocriptine and L-dopa or the alpha-adrenergic receptor blocker phenoxybenzamine elevated GnRH-R acutely from average basal values of 240 +/- 22 and 254 +/- 21 fmol/mg protein to maximal values of 374 +/- 49, 441 +/- 67 and 461 +/- 75 fmol/mg, respectively, whereas the alpha-adrenergic agonist clonidine transiently decreased GnRH-R to 186 +/- 19 fmol/mg.
Positive_regulation (elevated) of alpha-adrenergic receptor associated with agonist and clonidine
9) Confidence 0.02 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.98
Also, G-protein-coupled receptor activation of Src family members may result in activation of ERK1/2 via activation of Ras [17, 18] or via transactivation of the EGFR.
Positive_regulation (activation) of G-protein-coupled receptor
10) Confidence 0.02 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583213 Disease Relevance 0 Pain Relevance 0.06
In a patch clamp study using single brain neurons, naltrindole and naltriben both inhibited the currents caused by activation of G-protein-coupled inwardly rectifying K+ (GIRK) channel [14].
Positive_regulation (activation) of G-protein-coupled in brain
11) Confidence 0.01 Published 2007 Journal Cough Section Body Doc Link PMC1950526 Disease Relevance 0.18 Pain Relevance 0.66
In experiments performed with intact cells the same pattern could be seen: the basal production of cAMP was not affected when alpha2C-adrenoceptors were activated, but activated alpha2B-adrenoceptors mediated stimulation of cAMP production.
Positive_regulation (activated) of alpha2B
12) Confidence 0.01 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.18 Pain Relevance 0.07
In isolated cell membranes, activation of alpha2A- and alpha2C-adrenoceptors did not affect basal enzyme activity, but activation of alpha2B-adrenoceptors stimulated adenylyl cyclase activity.
Positive_regulation (activation) of alpha2B
13) Confidence 0.01 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.17 Pain Relevance 0.09
Our results suggest that alpha2B-adrenoceptors are coupled to both Gi and Gs proteins.
Positive_regulation (coupled) of alpha2B
14) Confidence 0.01 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.16 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox