INT301603

Context Info Confidence 0.33 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.66 Pain Relevance 0.32

small molecule metabolic process (CYP4F3) endoplasmic reticulum (CYP4F3)

CYP4F3 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 10 89.32 Inflammatory response 2 82.00 Inflammation 32 77.20 fibrosis 22 5.00 agonist 22 5.00 Bile 10 5.00 chemokine 8 5.00 Kinase C 6 5.00 cytokine 4 5.00 methotrexate 2 5.00

Disease Link Frequency Relevance Heat Starvation 16 100.00 INFLAMMATION 30 81.64 Fatty Liver 126 5.00 Nash(non-alcoholic Steatohepatitis) 54 5.00 Insulin Resistance 50 5.00 Metabolic Syndrome 46 5.00 Liver Disease 36 5.00 Diabetes Mellitus 34 5.00 Disease 26 5.00 Stress 24 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-hydroxylation of MCFAs by CYP4A P450s in rodents during fasting, by peroxisome proliferators, and in hepatic steatosis while decreased CYP4F genes expression by peroxisome proliferators and during starvation results in reduced ?

Negative_regulation (decreased) of Gene_expression (expression) of CYP4F associated with starvation

1) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.33 Pain Relevance 0.16

-hydroxylation of MCFAs by CYP4A P450s in rodents during fasting, by peroxisome proliferators, and in hepatic steatosis while decreased CYP4F genes expression by peroxisome proliferators and during starvation results in reduced ?

Negative_regulation (reduced) of Gene_expression (expression) of CYP4F associated with starvation

2) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.33 Pain Relevance 0.16

General Comments

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