INT301610

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4F2) endoplasmic reticulum (CYP4F2)
CYP4F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 55.20 Quite High
chemokine 8 54.08 Quite High
Inflammation 32 39.56 Quite Low
fibrosis 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatty Liver 126 98.68 Very High Very High Very High
Obesity 22 98.52 Very High Very High Very High
Liver Disease 36 83.60 Quite High
INFLAMMATION 30 39.56 Quite Low
Injury 16 34.20 Quite Low
Hyperglycemia 6 25.60 Quite Low
Celiac Disease 4 23.36 Low Low
Metabolic Syndrome 46 17.12 Low Low
Disease 26 11.20 Low Low
Nash(non-alcoholic Steatohepatitis) 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is currently unknown whether the human CYP4F2 gene is repressed by fatty acids in patients with NAFLD.
Spec (whether) Negative_regulation (repressed) of CYP4F2 associated with fatty liver
1) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.44 Pain Relevance 0
In contrast, the CYP4F2 gene has been shown to be downregulated by peroxisome proliferators [139], induced by retinoic acids [140], and its expression increased by lovastatin-mediated activation of SREBP-2 [141].
Negative_regulation (downregulated) of CYP4F2
2) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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