INT301612

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4A11) endoplasmic reticulum (CYP4A11)
Anatomy Link Frequency
liver 1
CYP4A11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 22 77.60 Quite High
cytokine 4 47.84 Quite Low
chemokine 8 46.72 Quite Low
Inflammation 32 35.24 Quite Low
fibrosis 22 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 46 99.96 Very High Very High Very High
Obesity 22 99.84 Very High Very High Very High
Fatty Liver 126 99.32 Very High Very High Very High
Disease Progression 6 95.16 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 54 79.24 Quite High
Liver Disease 36 76.24 Quite High
Stress 24 69.36 Quite High
Hyperoxia 2 67.72 Quite High
INFLAMMATION 30 35.24 Quite Low
Adrenoleukodystrophy 4 33.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, one study suggested that the human CYP4A11 mRNA was reduced in obese individuals [126].
Negative_regulation (reduced) of CYP4A11 associated with obesity
1) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.44 Pain Relevance 0
In humans with obesity, CYP4A11 mRNA decreased by 50% while in NAFLD patients while CYP4A11 mRNA increases 4-fold [126], suggesting a differential regulation in liver disease progression.
Negative_regulation (decreased) of CYP4A11 in liver associated with fatty liver, metabolic syndrome and disease progression
2) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.70 Pain Relevance 0.07

General Comments

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