INT301626

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk8, Irs1) cytosol (Mapk8, Irs1) signal transduction (Mapk8, Irs1)
nucleus (Mapk8, Irs1) mitochondrion (Mapk8) signal transducer activity (Irs1)
Mapk8 (Mus musculus)
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 85.28 High High
Kinase C 3 49.04 Quite Low
Inflammation 16 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 25 90.04 High High
Diabetes Mellitus 17 87.08 High High
Impaired Glucose Tolerance 1 85.52 High High
Stress 12 84.72 Quite High
Obesity 11 74.88 Quite High
Hyperinsulinism 3 73.64 Quite High
Apoptosis 6 41.12 Quite Low
Metabolic Syndrome 23 29.00 Quite Low
Hepatocellular Cancer 5 9.20 Low Low
Liver Failure 1 5.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JNK-mediated decreased activation of IRS-1 also results in reduced suppression of FOXO1, leading to increased hepatic gluconeogenesis.
JNK Positive_regulation (activation) of IRS-1
1) Confidence 0.09 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.83 Pain Relevance 0.04

General Comments

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