INT301637

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) extracellular space (Ins1)
signal transduction (Ros1) extracellular region (Ins1) plasma membrane (Ros1)
Ros1 (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 96.96 Very High Very High Very High
Kinase C 3 93.96 High High
fibrosis 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 96.96 Very High Very High Very High
Insulin Resistance 25 93.32 High High
Metabolic Syndrome 23 82.48 Quite High
Liver Disease 18 81.28 Quite High
Obesity 11 78.96 Quite High
Diabetes Mellitus 17 76.80 Quite High
Repression 2 39.00 Quite Low
Fatty Liver 63 22.48 Low Low
Nash(non-alcoholic Steatohepatitis) 27 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation JNK and/or p38 kinase especially by saturated FFAs and increased ROS [151, 152] leads to serine phosphorylation and inhibition of insulin receptor substrates IRS-1 and IRS-2, resulting in decreased insulin signaling (i.e., decreased Tyrosine phosphorylation) and increased hepatic gluconeogenesis during insulin resistance.
Positive_regulation (increased) of ROS Positive_regulation (leads) of Phosphorylation (phosphorylation) of insulin associated with insulin resistance
1) Confidence 0.00 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.91 Pain Relevance 0.10

General Comments

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