INT301641

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Irs2, Pck1) lyase activity (Pck1) lipid metabolic process (Pck1)
signal transducer activity (Irs2) cytosol (Irs2) cell proliferation (Irs2)
Irs2 (Mus musculus)
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 81.80 Quite High
cytokine 2 71.04 Quite High
fibrosis 11 33.92 Quite Low
Inflammation 16 30.52 Quite Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 94.88 High High
Insulin Resistance 25 88.96 High High
Stress 12 71.92 Quite High
Diabetes Mellitus 17 67.44 Quite High
Metabolic Syndrome 23 61.76 Quite High
Obesity 11 56.92 Quite High
Hepatocellular Cancer 5 39.88 Quite Low
Liver Failure 1 38.28 Quite Low
Hepatic Encephalopathy 1 37.52 Quite Low
Cirrhosis 8 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both IRS-1 and IRS-2 inhibit the transcription factor FOXO-mediated gene transcription of PEPCK, G6Pase, and PGC-1?
IRS-2 Negative_regulation (inhibit) of Transcription (transcription) of PEPCK
1) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.65 Pain Relevance 0.08

General Comments

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