INT301646

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Srebf1, Irs2) Golgi apparatus (Srebf1) endoplasmic reticulum (Srebf1)
DNA binding (Srebf1) protein complex (Srebf1) signal transducer activity (Irs2)
Srebf1 (Mus musculus)
Irs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 83.28 Quite High
Kinase C 3 74.40 Quite High
fibrosis 11 26.52 Quite Low
Inflammation 16 23.12 Low Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 99.50 Very High Very High Very High
Insulin Resistance 25 93.68 High High
Stress 12 84.16 Quite High
Diabetes Mellitus 17 79.68 Quite High
Metabolic Syndrome 23 54.36 Quite High
Obesity 11 49.52 Quite Low
Impaired Glucose Tolerance 1 35.28 Quite Low
Hepatocellular Cancer 5 32.48 Quite Low
Liver Failure 1 30.88 Quite Low
Hepatic Encephalopathy 1 30.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased activation of IRS-1 during hyperinsulinemia increases expression of SREBP-1c, which normally blocks IRS-2 expression and CREBP critical for hepatic gluconeogenesis.
SREBP-1c Negative_regulation (blocks) of Gene_expression (expression) of IRS-2 associated with hyperinsulinism
1) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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