INT30165

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Context Info
Confidence 0.56
First Reported 1985
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.75
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
4th ventricle 2
neurons 2
superior cervical ganglion 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 7 100.00 Very High Very High Very High
Morphine 34 99.68 Very High Very High Very High
withdrawal 21 99.36 Very High Very High Very High
addiction 5 82.20 Quite High
antagonist 2 80.76 Quite High
narcan 12 80.36 Quite High
Potency 2 79.96 Quite High
tetrodotoxin 2 78.52 Quite High
Neuronal nitric oxide synthase 1 78.48 Quite High
Opioid 1 77.20 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.96 Very High Very High Very High
Opiate Addiction 1 77.64 Quite High
Attention Deficit Hyperactivity Disorder 3 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data support the hypothesis that low-Na+ medium stimulates DOPA synthesis by raising intracellular Ca2+, which then promotes the phosphorylation of tyrosine hydroxylase.
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of tyrosine hydroxylase
1) Confidence 0.56 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.22 Pain Relevance 0.15
Low-Na+ medium increases the activity and the phosphorylation of tyrosine hydroxylase in the superior cervical ganglion of the rat.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of tyrosine hydroxylase in superior cervical ganglion associated with ganglion cysts
2) Confidence 0.56 Published 1985 Journal J. Neurochem. Section Title Doc Link 2857766 Disease Relevance 0.34 Pain Relevance 0.14
However, this inhibitor neither modifies the morphine withdrawal induced Fos expression nor the increase of nonphosphorylated TH levels.
Neg (nor) Positive_regulation (increase) of Phosphorylation (nonphosphorylated) of TH associated with withdrawal and morphine
3) Confidence 0.51 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.13 Pain Relevance 1.48
When HA-1004 (40 nmol/day), inhibitor of cyclic AMP dependent protein kinase (PKA) was infused, concomitantly with morphine, it diminished the increase in noradrenaline (NA) turnover, total TH expression (95.76 +/- 4.1 %, P < 0.01) and TH phosphorylation at Ser40 (85.5 +/- 11%, P < 0.01) in morphine-withdrawn rats.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TH associated with noradrenaline and morphine
4) Confidence 0.47 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.06 Pain Relevance 1.25
The present findings demonstrate that the enhancement of total TH expression and the increase of the phosphorylation state of TH during morphine withdrawal are dependent on PKA and ERK and suggest that these transduction pathways might contribute to the activation of the cardiac catecholaminergic neurons in response to morphine- withdrawal.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TH in neurons associated with withdrawal and morphine
5) Confidence 0.41 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0 Pain Relevance 1.02
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Positive_regulation (accumulation) of Phosphorylation (phosphorylation) of TH mRNA
6) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Positive_regulation (butyrate-induced) of Phosphorylation (phosphorylation) of TH mRNA
7) Confidence 0.19 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Using Western blot analysis, we show that the robust increase in tyrosine hydroxylase phosphorylation obtained with intraperitoneal CCK is significantly attenuated in rats pretreated with the ERK-pathway blocker U0126 injected into the 4th ventricle.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of tyrosine hydroxylase in 4th ventricle
8) Confidence 0.19 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19176891 Disease Relevance 0 Pain Relevance 0.18

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