INT301656

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ins1, Srebf1) Golgi apparatus (Srebf1) endoplasmic reticulum (Srebf1)
DNA binding (Srebf1) carbohydrate metabolic process (Ins1) protein complex (Srebf1)
Anatomy Link Frequency
hepatocytes 1
Ins1 (Mus musculus)
Srebf1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 22 84.92 Quite High
Bile 10 53.16 Quite High
fibrosis 22 27.40 Quite Low
Inflammation 32 26.36 Quite Low
alcohol 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 22 98.80 Very High Very High Very High
Insulin Resistance 50 77.96 Quite High
Hyperinsulinism 6 76.72 Quite High
Stress 24 59.92 Quite High
Fatty Liver 126 57.36 Quite High
Metabolic Syndrome 46 55.56 Quite High
Liver Disease 36 49.24 Quite Low
Targeted Disruption 14 39.16 Quite Low
Nash(non-alcoholic Steatohepatitis) 54 27.72 Quite Low
Fibrosis 16 27.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These genes are activated through insulin-mediated activation of two transcription factors (e.g., SREBP-1c and ChREBP).
insulin Positive_regulation (activation) of SREBP-1c
1) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.36 Pain Relevance 0
It is therefore not surprising that FATP2 is induced in obese Zucker (fa/fa) rats and that both FATP2 and FATP4 mRNA are increased in hepatocytes by carbohydrates feeding and by insulin through SREBP-1c [35].
insulin Positive_regulation (increased) of SREBP-1c in hepatocytes associated with obesity
2) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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