INT301659

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk8, Srebf1) nucleus (Mapk8, Srebf1) mitochondrion (Mapk8)
Golgi apparatus (Srebf1) endoplasmic reticulum (Srebf1) DNA binding (Srebf1)
Anatomy Link Frequency
fat 3
Mapk8 (Mus musculus)
Srebf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 93.40 High High
Kinase C 3 57.16 Quite High
fibrosis 11 9.28 Low Low
Inflammation 16 5.88 Low Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 25 98.16 Very High Very High Very High
Diabetes Mellitus 17 95.20 Very High Very High Very High
Stress 12 92.84 High High
Hyperinsulinism 3 81.76 Quite High
Impaired Glucose Tolerance 1 78.00 Quite High
Obesity 11 67.36 Quite High
Metabolic Syndrome 23 37.12 Quite Low
Apoptosis 6 33.60 Quite Low
Hepatocellular Cancer 5 15.24 Low Low
Liver Failure 1 13.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JNK adenovirus overexpression increases serine phosphorylation of IRS-1 with decreased IRS-1 tyrosine phosphorylation and increased SREBP-1c activation, resulting in increased fat synthesis and storage.
Gene_expression (overexpression) of JNK in fat Positive_regulation (increased) of Positive_regulation (activation) of SREBP-1c in fat
1) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.80 Pain Relevance 0.08

General Comments

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