INT301662

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr4, CYBB) cytoplasm (Tlr4, CYBB) mitochondrion (CYBB)
signal transduction (Tlr4) oxidoreductase activity (CYBB) intracellular (Tlr4)
Tlr4 (Mus musculus)
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 11 68.28 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 27 86.28 High High
Fatty Liver 63 85.96 High High
Parkinson's Disease 4 83.28 Quite High
Injury 8 74.52 Quite High
Insulin Resistance 25 71.68 Quite High
Cirrhosis 8 68.28 Quite High
Apoptosis 6 67.52 Quite High
Fibrosis 8 41.28 Quite Low
Targeted Disruption 7 31.16 Quite Low
Hepatocellular Cancer 5 7.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that PUFAs inhibit TLR4 dimerization, which promotes the production of NADPH oxidase-dependent ROS, which is believed to be the second hit in the progression of steatosis to steatohepatitis.

5.

TLR4 Binding (dimerization) of Positive_regulation (promotes) of Gene_expression (production) of NADPH oxidase
1) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.84 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox