INT301662

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.84 Pain Relevance 0.03

plasma membrane (Tlr4, CYBB) cytoplasm (Tlr4, CYBB) mitochondrion (CYBB) signal transduction (Tlr4) oxidoreductase activity (CYBB) intracellular (Tlr4)

Tlr4 (Mus musculus) CYBB (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 11 68.28 Inflammation 16 5.00 agonist 11 5.00 alcohol 5 5.00 Bile 5 5.00 chemokine 4 5.00 Kinase C 3 5.00 cytokine 2 5.00 methotrexate 1 5.00 fluoxetine 1 5.00

Disease Link Frequency Relevance Heat Nash(non-alcoholic Steatohepatitis) 27 86.28 Fatty Liver 63 85.96 Parkinson's Disease 4 83.28 Injury 8 74.52 Insulin Resistance 25 71.68 Cirrhosis 8 68.28 Apoptosis 6 67.52 Fibrosis 8 41.28 Targeted Disruption 7 31.16 Hepatocellular Cancer 5 7.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is interesting that PUFAs inhibit TLR4 dimerization, which promotes the production of NADPH oxidase-dependent ROS, which is believed to be the second hit in the progression of steatosis to steatohepatitis. 5.

TLR4 Binding (dimerization) of Positive_regulation (promotes) of Gene_expression (production) of NADPH oxidase

1) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.84 Pain Relevance 0.03

General Comments

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