INT301666

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.57
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) small molecule metabolic process (CYP4F2) endoplasmic reticulum (CYP4F2)
plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
liver 2
skin 1
kidney 1
CYP4F2 (Homo sapiens)
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 64 78.32 Quite High
Inflammatory response 4 60.80 Quite High
alcohol 20 45.04 Quite Low
fibrosis 44 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Bile 20 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 78.32 Quite High
Starvation 32 46.24 Quite Low
Toxicity 20 13.24 Low Low
Fatty Liver 252 5.00 Very Low Very Low Very Low
Nash(non-alcoholic Steatohepatitis) 108 5.00 Very Low Very Low Very Low
Insulin Resistance 100 5.00 Very Low Very Low Very Low
Metabolic Syndrome 92 5.00 Very Low Very Low Very Low
Liver Disease 72 5.00 Very Low Very Low Very Low
Diabetes Mellitus 68 5.00 Very Low Very Low Very Low
Disease 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
CYP4F2 Binding (affinity) of LTB4 in skin
1) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06
However, CYP4F3B splice variant of the CYP4F3 gene expressed in liver and has a similar affinity as CYP4F2 for LTB4 [122].
CYP4F2 Binding (affinity) of LTB4 in liver
2) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.21 Pain Relevance 0.10
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
CYP4F2 Binding (affinity) of LTB4 in liver
3) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06
The human CYP4F P450s metabolize and inactivate the proinflammatory leukotriene B4 (LTB4) [118], with the myeloid-expressed CYP4F3A having a twofold greater affinity for LTB4 than CYP4F2 expressed in liver, kidney, and skin, but not in myeloid cells.
CYP4F2 Binding (affinity) of LTB4 in kidney
4) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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