INT30169

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 107
Total Number 129
Disease Relevance 81.00
Pain Relevance 36.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
lung 9
striatum 4
neutrophils 3
smooth muscle 2
cardiomyocytes 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 116 100.00 Very High Very High Very High
Leflunomide 200 99.96 Very High Very High Very High
rheumatoid arthritis 451 99.92 Very High Very High Very High
Inflammatory mediators 104 99.92 Very High Very High Very High
Inflammation 4369 99.84 Very High Very High Very High
long-term potentiation 175 99.84 Very High Very High Very High
antidepressant 52 99.68 Very High Very High Very High
Inflammatory marker 56 99.64 Very High Very High Very High
fibrosis 1068 99.40 Very High Very High Very High
cINOD 43 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Granuloma 750 99.92 Very High Very High Very High
Rheumatoid Arthritis 476 99.92 Very High Very High Very High
Pulmonary Disease 3893 99.88 Very High Very High Very High
INFLAMMATION 4639 99.84 Very High Very High Very High
Asthma 1612 99.72 Very High Very High Very High
Pneumonia 252 99.52 Very High Very High Very High
Fibrosis 532 99.40 Very High Very High Very High
Eosinophilia 25 99.08 Very High Very High Very High
Pulmonary Fibrosis 560 98.96 Very High Very High Very High
Pathologic Processes 30 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hippocampus, antidepressants increased PDE4A and decreased PDE4B, whereas ROL decreased PDE4A and did not change PDE4B.
Negative_regulation (decreased) of PDE4A in hippocampus associated with antidepressant and hippocampus
1) Confidence 0.58 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.79
This reduced expression was accompanied by a reduction in PDE4 activity, while non-PDE4 activity was unchanged.
Negative_regulation (reduction) of PDE4
2) Confidence 0.57 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.19 Pain Relevance 0.45
Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals; however, it is not known which of the four PDE4 subtypes mediates these actions.
Negative_regulation (inhibition) of PDE4 associated with antidepressant and adenocard
3) Confidence 0.57 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.15 Pain Relevance 0.22
In the prefrontal cortex, PDE4 activity was significantly reduced in both low and high stereotypic mice compared to their non-stereotypic controls, while in the striatum, only high stereotypic mice showed a significant reduction in PDE4 activity.
Negative_regulation (reduced) of PDE4 in striatum
4) Confidence 0.48 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463268 Disease Relevance 0 Pain Relevance 0.41
Spontaneous stereotypy in deer mice is thus characterized by raised cAMP and reduced PDE4 enzyme activity, particularly in the prefrontal cortex, and is modified by chronic treatment with fluoxetine.
Negative_regulation (reduced) of PDE4 in cortex associated with fluoxetine
5) Confidence 0.48 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463268 Disease Relevance 0 Pain Relevance 0.41
Fluoxetine significantly attenuated stereotypies in high stereotypic animals, together with a reduction in cortical cAMP levels and PDE4 activity, without noteworthy effects in the striatum.
Negative_regulation (reduction) of PDE4 in striatum associated with fluoxetine
6) Confidence 0.48 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463268 Disease Relevance 0 Pain Relevance 0.42
In the prefrontal cortex, PDE4 activity was significantly reduced in both low and high stereotypic mice compared to their non-stereotypic controls, while in the striatum, only high stereotypic mice showed a significant reduction in PDE4 activity.
Negative_regulation (reduction) of PDE4 in striatum
7) Confidence 0.48 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463268 Disease Relevance 0 Pain Relevance 0.42
Selective inhibition of PDE 4 suppresses several eosinophil functions such as superoxide anion generation [33], adhesion and migration [34].
Negative_regulation (inhibition) of PDE 4 in eosinophil associated with adhesions
8) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.95 Pain Relevance 0.45
To date, however, very little is known regarding the potential interaction between selective inhibitors of PDE 3, PDE 4 and PDE 5.
Negative_regulation (inhibitors) of PDE 4
9) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.46 Pain Relevance 0.15
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
Negative_regulation (inhibitor) of PDE 4
10) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.95 Pain Relevance 0.29
In passively sensitised human airways, allergen-induced contraction was inhibited only by the simultaneous inhibition of PDE 3 and PDE 4 and not by single inhibition of either family [25].
Negative_regulation (inhibition) of PDE 4
11) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.50 Pain Relevance 0.15
A major aspect of this study was to examine the possible interaction between inhibitors of the PDE 3, PDE 4 or PDE 5 families.
Spec (possible) Negative_regulation (inhibitors) of PDE 4
12) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.45 Pain Relevance 0.19
In the prefrontal cortex, PDE4 activity was significantly reduced in both low and high stereotypic mice compared to their non-stereotypic controls, while in the striatum, only high stereotypic mice showed a significant reduction in PDE4 activity.
Negative_regulation (reduction) of PDE4 in striatum
13) Confidence 0.35 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463268 Disease Relevance 0 Pain Relevance 0.44
1AR even though it has been shown that PDE4 inhibitors potentiate cAMP accumulation induced by either ?
Negative_regulation (inhibitors) of PDE4
14) Confidence 0.34 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.03
Indeed, when PDE4 activity is inhibited in cardiomyocytes (Figure 6A and B), is absent, as in the PDE4D-deficient MEFs (Figure 6C and D), or is displaced, as in PDE4D-DN infected cardiomyocytes (Figure 6E and F), a substantial increase in basal ?
Negative_regulation (inhibited) of PDE4 in cardiomyocytes
15) Confidence 0.33 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.06
PDE4 and PDE3 activity are defined as the PDE activity inhibited by the PDE4-selective inhibitor, Rolipram (10 ?
Negative_regulation (defined) of PDE4
16) Confidence 0.33 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.15
1AR IP, cardiomyocytes deficient in PDE4A, PDE4B, and PDE4D were subjected to pull-down experiments.
Negative_regulation (deficient) of PDE4A in cardiomyocytes
17) Confidence 0.33 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
Members of both families are also expressed in cells of the immune system and considerable attention has been focussed on the potential of selective inhibitors of PDE 3 and PDE 4, or in combination, for the treatment of asthma and other inflammatory diseases [17-21].
Negative_regulation (inhibitors) of PDE 4 in immune system associated with asthma, inflammation and disease
18) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.75 Pain Relevance 0.23
An enhancing effect with one of these combinations, compared to the effects of a PDE 4 inhibitor alone, could suggest this as a possible preferential treatment for inflammatory conditions.
Negative_regulation (inhibitor) of PDE 4 associated with inflammation
19) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.51 Pain Relevance 0.19
the combining of PDE inhibitors resulted in no additive effects in the reduction of IL-5, and reduced the effects of the PDE 4 inhibitor on its own.


Negative_regulation (inhibitor) of PDE 4
20) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.07 Pain Relevance 0.11

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