INT30170

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Context Info
Confidence 0.66
First Reported 1983
Last Reported 2011
Negated 16
Speculated 9
Reported most in Body
Documents 330
Total Number 339
Disease Relevance 77.26
Pain Relevance 46.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
neurons 27
cardiomyocytes 9
astrocytes 8
brain 5
reticulum 5
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2121 100.00 Very High Very High Very High
Pyramidal cell 402 100.00 Very High Very High Very High
Morphine 330 100.00 Very High Very High Very High
Kinase C 295 100.00 Very High Very High Very High
antagonist 685 99.96 Very High Very High Very High
Hippocampus 775 99.86 Very High Very High Very High
cINOD 751 99.84 Very High Very High Very High
Nicotine 7 99.74 Very High Very High Very High
Paracetamol 10 99.64 Very High Very High Very High
addiction 432 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1790 100.00 Very High Very High Very High
Stress 1195 100.00 Very High Very High Very High
Adhesions 84 100.00 Very High Very High Very High
Aging 1503 99.90 Very High Very High Very High
Arrhythmia Under Development 109 99.90 Very High Very High Very High
Channelopathies 87 99.90 Very High Very High Very High
Disease 2504 99.86 Very High Very High Very High
Alzheimer's Dementia 234 99.86 Very High Very High Very High
Ocular Hypertension 211 99.84 Very High Very High Very High
Overdose 6 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also is possible that CAII substantially contributes to aqueous humor secretion but that functional mouse CAIV is sufficient to prevent an effect of CAII deficiency on IOP in Car2 mutant mice.
Gene_expression (deficiency) of CAII associated with ocular hypertension
1) Confidence 0.66 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.01 Pain Relevance 0
However, spontaneously driven Ca2+ transients in acute brain slices from transgenic mtGA newborn mice were readily detectable.
Gene_expression (detectable) of Ca2 in brain associated with targeted disruption
2) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.10 Pain Relevance 0.03
In another approach, a genetically encoded Ca2+ sensitive probe was expressed in the muscles of live animals and gave accurate information about [Ca2+] in the mitochondrial matrix ([Ca2+]m) during relaxation/contraction cycles [8].
Gene_expression (expressed) of Ca2 in muscles
3) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.13
Western blot analysis of calsequestrin and sarcoendoplasmic reticulum Ca2+-ATPase 1 (SERCA1)
Gene_expression (sarcoendoplasmic) of Ca2 in reticulum
4) Confidence 0.56 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
Western blot analysis of calsequestrin and sarcoendoplasmic reticulum Ca2+-ATPase 1 (SERCA1)
Gene_expression (analysis) of Ca2 in reticulum
5) Confidence 0.56 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
Oscillatory rises in Ca2+ were absent or significantly reduced after incubation with the NADH-ubiquinone oxidoreductase (complex I) inhibitor, piericidin A (2 µM) (Figure 2C, n?
Neg (absent) Gene_expression (rises) of Ca2
6) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.29
Ca2+ sensitive CRET activities on cellular extracts and transgenic mouse tissue
Gene_expression (activities) of Ca2 associated with targeted disruption
7) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.18 Pain Relevance 0
Oscillatory rises in Ca2+ were absent or significantly reduced after incubation with the NADH-ubiquinone oxidoreductase (complex I) inhibitor, piericidin A (2 µM) (Figure 2C, n?
Neg (absent) Gene_expression (absent) of Ca2
8) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.29
Overall, the percentage of time recorded in the absence of sustained Ca2+ responses was 88.5±3.5 % (n?
Gene_expression (responses) of Ca2
9) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0
Elevated Ca2+ activity appeared both as a slow rise in the basal concentration and as oscillations in which Ca2+ spikes only lasted a few seconds (Figure 7B & C, (ii) & (iii)).
Gene_expression (spikes) of Ca2 in spikes
10) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.22 Pain Relevance 0.08
Non-invasive, high resolution in vivo detection of Ca2+ signals
Gene_expression (signals) of Ca2
11) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.13
Naturally, this new technique bears some limitations, such as the difficulty to detect Ca2+-signals in deep tissues like the brain.
Gene_expression (detect) of Ca2 in brain associated with deep tissue
12) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.14 Pain Relevance 0.05
The relationship between Ca2+ responses in the neocortex and motion episodes was recently studied in newborn mice [9].
Gene_expression (responses) of Ca2 in neocortex
13) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.06 Pain Relevance 0
Finally, using bioluminescence for imaging over long periods can also reveal other interesting phenomena, such as Ca2+ waves occurring across the entire animal, which were observed after kainate induced seizures (Figure 7D (n?
Gene_expression (waves) of Ca2 associated with convulsion and imagery
14) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.28 Pain Relevance 0.08
Sustained Ca2+ responses in the older animals also had more complex patterns (see Figure 6B (i) versus 6B (iii)).
Gene_expression (responses) of Ca2
15) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0
The present study does not support earlier published findings, which suggested that several behaviourally active drugs produce significant decreases of brain Ca2+.
Gene_expression (produce) of Ca2 in brain
16) Confidence 0.53 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6419254 Disease Relevance 0.16 Pain Relevance 0.11
The results suggest that pacemaker [Ca2+]i oscillations in ICCs are produced by close interaction of intracellular Ca2+ release channels, especially inositol 1,4,5-trisphosphate receptor (InsP3R) and Ca2+ influx pathways, presumably corresponding to store-operated type channels.
Gene_expression (produced) of Ca2
17) Confidence 0.52 Published 2005 Journal J. Biol. Rhythms Section Abstract Doc Link 15654067 Disease Relevance 0 Pain Relevance 0.11
For all experiments in slices cultures as well as for in vivo two-photon imaging, Ca2+ signals were expressed as relative YFP/CFP ratio changes ?
Gene_expression (expressed) of Ca2 associated with imagery
18) Confidence 0.52 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.19
Viral delivery of FCIPs may in the future be combined with the powerful tools of mouse genetics, allowing for cell-type specific or inducible expression of Ca2+ sensors (Zhu et al., 2007; Wallace et al., 2008).
Gene_expression (expression) of Ca2
19) Confidence 0.52 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.07
Schipke et al. showed that electrical stimulation of astrocytes produced Ca2+ waves that triggered Ca2+ responses in microglia in an extracellular ATPdependent manner in a slice preparation of mouse.
Gene_expression (produced) of Ca2 in astrocytes
20) Confidence 0.51 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096541 Disease Relevance 0.12 Pain Relevance 0.10

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