INT30171

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Context Info
Confidence 0.73
First Reported 1985
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 0.58
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Calm3)
Anatomy Link Frequency
neurons 1
Calm3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 7 99.86 Very High Very High Very High
opioid receptor 90 99.72 Very High Very High Very High
Morphine 95 97.84 Very High Very High Very High
narcan 3 96.00 Very High Very High Very High
addiction 7 91.16 High High
Calcium channel 3 90.00 High High
nMDA receptor 3 87.96 High High
depression 63 86.40 High High
dopamine receptor 9 86.24 High High
Serotonin 7 84.64 Quite High
Disease Link Frequency Relevance Heat
Depression 63 86.40 High High
Calcification 2 76.24 Quite High
Aging 1 75.00 Quite High
Channelopathies 34 50.00 Quite Low
Adhesions 14 21.72 Low Low
Hypokalemic Periodic Paralysis 58 5.00 Very Low Very Low Very Low
Disease 28 5.00 Very Low Very Low Very Low
Dystonia 20 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Night Blindness 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CaM was increased in dose- and time-dependent manners by morphine with RT-PCR assay in PC12 cells, and naloxone inhibited the effect of morphine.
Gene_expression (Expression) of CaM associated with narcan and morphine
1) Confidence 0.73 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11202613 Disease Relevance 0 Pain Relevance 0.76
Increase of calmodulin III gene expression by mu-opioid receptor stimulation in PC12 cells.
Gene_expression (expression) of calmodulin III gene associated with opioid receptor
2) Confidence 0.73 Published 2000 Journal Jpn. J. Pharmacol. Section Title Doc Link 11202613 Disease Relevance 0 Pain Relevance 0.72
One hour after injections and 72 h after pellet implantations, the mice were decapitated and striatal regions were removed for the following analyses: calmodulin (CaM) levels via radioimmunoassay and activities of cyclic nucleotide phosphodiesterases, adenylate and guanylate cyclases, and Ca2+, Mg2+-ATPase.
Spec (analyses) Gene_expression (levels) of CaM
3) Confidence 0.49 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857771 Disease Relevance 0.07 Pain Relevance 0.39
-CaMKII has 10-fold higher affinity for Ca2+/CaM than ?
Gene_expression (has) of CaM
4) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
In addition, we showed that the CaMKII-mediated reduction of PDE1 affinity with Ca2+/CaM forms another positive-feedback loop.
Gene_expression (reduction) of CaM
5) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
When Thr286/287 is phosphorylated, CaMKII maintains its enzymatic activity in the absence of Ca2+/CaM (Miller and Kennedy, 1986; Lisman et al, 2002), which would contribute to the maintenance of long-lasting potentiation of synaptic transmission.
Neg (absence) Gene_expression (absence) of CaM
6) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
-CaMKII has 10-fold higher affinity for Ca2+/CaM than ?
Gene_expression (/) of CaM
7) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
-CaMKII has 10-fold higher affinity for Ca2+/CaM than ?
Gene_expression (than) of CaM
8) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
On the other hand, the amounts of active Ca2+/CaM, calcineurin, and adenylyl cyclase after the Ca2+ stimulation returned to their respective basal levels (Figure 2C, D and F).
Gene_expression (/) of CaM
9) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.04
In Purkinje neurons, unlike hippocampal CA1 pyramidal neurons, Ca2+/CaM-activated adenylyl cyclases such as type-1 and type-8 are not expressed (Cooper et al, 1995).
Neg (not) Gene_expression (expressed) of CaM in neurons associated with pyramidal cell
10) Confidence 0.22 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.43 Pain Relevance 0.39
Ca2+-CaM then increases and activates CaMKII (13) that, in turn, acts on nNOS Ser847 to reduce Ca2+-CaM binding and NO production (14).
Neg (NO) Gene_expression (production) of CaM
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.45
CaMKII was included in the model as a buffer for CaM; therefore only three reactions are included: reversible binding of CaM to CaMKII; a slow autophosphorylation into CaMKIIp, in which CaM is trapped; and dephosphorylation of CaMKIIp by PP1.
Gene_expression (trapped) of CaM
12) Confidence 0.14 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.12
Fig. 5Hypothetical model of Cav1.4 C-terminal modulation. a Motifs previously demonstrated to be important for CaM modulation of other Ca2+ isoforms (red: EF hand; green: pre-IQ regions, IQ domain) are illustrated.
Gene_expression (modulation) of CaM
13) Confidence 0.08 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0 Pain Relevance 0
Protein–protein interactions of C-terminal channel fragments and CaM expressed in HEK-293 cells measured using fluorescence resonance energy transfer (FRET), revealed that at resting calcium concentrations, apo-CaM binds to a C-terminal fragment containing the known CaM binding domains identified previously in other L-type Ca2+ channels (pre-IQ, IQ domains; [23, 60, 94]).
Gene_expression (expressed) of CaM
14) Confidence 0.07 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.08 Pain Relevance 0.07

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