INT30172

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
spinal cord 1
Pde2a (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 14 100.00 Very High Very High Very High
Eae 9 99.84 Very High Very High Very High
allodynia 10 99.38 Very High Very High Very High
Morphine 22 98.80 Very High Very High Very High
MU agonist 1 97.28 Very High Very High Very High
Serotonin 12 93.64 High High
Dopamine 10 91.84 High High
Spinal cord 29 91.60 High High
Analgesic 3 87.64 High High
agonist 1 84.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 99.38 Very High Very High Very High
Nociception 25 86.04 High High
Inflammatory Pain 4 84.52 Quite High
Aging 1 75.00 Quite High
Sprains And Strains 4 67.76 Quite High
Pain 13 22.20 Low Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ibogaine pretreatment reduced both the cocaine and the CGS-12066A cocaine-induced increase in locomotor activity.
Positive_regulation (increase) of CGS-12066A associated with eae and cocaine
1) Confidence 0.39 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8801590 Disease Relevance 0 Pain Relevance 1.79
The only changes found in striata from morphine-tolerant mice when compared with age-matched controls were elevations in cyclic GMP-phosphodiesterase activities in all three age groups.
Positive_regulation (elevations) of cyclic GMP-phosphodiesterase associated with morphine
2) Confidence 0.23 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857771 Disease Relevance 0.07 Pain Relevance 0.45
The principal observations of our studies were, 1) C57Bl/6J mice display not only robust phase I/II licking behaviour after formalin injection, but also a long lasting mechanical allodynia, 2) the majority of the CO/NO-cGMP genes selected for study had correspondingly elevated mRNA levels at some time point within 48 hours of formalin injection, 3) of the genes showing increased mRNA levels at some time point, most of those had correspondingly elevated protein levels as measured in spinal cord homogenates collected 48 hours after formalin injection, and 4) pre-treatment with the analgesic morphine eliminated the acute nociceptive response to formalin injection as well as the delayed changes in spinal cord protein expression, but not chronic nociceptive sensitisation.
Positive_regulation (elevated) of cGMP in spinal cord associated with nociception, allodynia, analgesic, morphine and spinal cord
3) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.48 Pain Relevance 0.53

General Comments

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