INT301728

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dtna) cytoplasm (Dtna)
Anatomy Link Frequency
synapses 1
Dtna (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 16 96.28 Very High Very High Very High
Hippocampus 24 95.24 Very High Very High Very High
amygdala 10 66.12 Quite High
Pyramidal cell 8 48.96 Quite Low
Neurotransmitter 44 13.28 Low Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 14 100.00 Very High Very High Very High
Hypersensitivity 2 93.96 High High
Targeted Disruption 30 90.36 High High
Cerebellar Diseases 2 88.76 High High
Attention Deficit Hyperactivity Disorder 4 83.28 Quite High
Intellectual Impairment 14 71.84 Quite High
Muscular Dystrophy 92 69.28 Quite High
Anxiety Disorder 4 64.84 Quite High
Apoptosis 8 31.44 Quite Low
Cognitive Disorder 24 19.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, studies are reviewed that indicate that a number of the DGC members (dystrophin, dystrobrevin, syntrophin, and dystroglycan) are present at the postsynaptic side of mammalian inhibitory GABAergic synapses in the hippocampus and in cerebellar Purkinje cells [135], where they are required for synapse function and plasticity.
Negative_regulation (number) of dystrobrevin in synapses associated with gabaergic and hippocampus
1) Confidence 0.11 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.47 Pain Relevance 0.16
The loss of other worm DGC members, i.e., dystrobrevin or syntrophin, also gives rise to increased cholinergic activity [97].
Negative_regulation (loss) of dystrobrevin associated with helminth infection
2) Confidence 0.10 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.51 Pain Relevance 0

General Comments

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