INT301729

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
myoblasts 2
muscle 2
fibroblast 2
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 16 7.80 Low Low
Neurotransmitter 22 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
amygdala 5 5.00 Very Low Very Low Very Low
anticonvulsant 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 12 94.64 High High
Attention Deficit Hyperactivity Disorder 2 89.76 High High
Hypopituitarism 40 85.28 High High
Targeted Disruption 39 81.00 Quite High
Helminth Infection 7 79.60 Quite High
Hypersensitivity 13 72.84 Quite High
Disease 25 68.88 Quite High
Muscular Dystrophy 46 65.36 Quite High
Viral Infection 4 54.00 Quite High
Frailty 43 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. (1B), MYOD protein expression was barely detectable by Western blot 24 h after treatment of immortalized fibroblasts with doxycycline (myoblasts), but was significantly increased upon differentiation of myoblasts into myotubes for 3-7 days.
Positive_regulation (increased) of Gene_expression (expression) of MYOD in myoblasts
1) Confidence 0.24 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.31 Pain Relevance 0
Use of fibroblasts as a starting point allowed monitoring of myogenic differentiation defects in DM1 cells upon inducible overexpression of MYOD, the sole transcription factor necessary to convert fibroblast cells into myoblasts [44].
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYOD in fibroblast
2) Confidence 0.24 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.34 Pain Relevance 0
Generation of Inducible MYOD Construct
Positive_regulation (Generation) of Gene_expression (Generation) of MYOD
3) Confidence 0.17 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.32 Pain Relevance 0
Lentivirus expressing MYOD or CLCN1-luc was produced by co-transfection of 10 µg MyoD/pTREautoR3 or CLCN1-luc/pLenti6/V5-D-TOPO DNA with RRE, REV and VSV-g packaging vectors (6.5 µg, 2.5 µg and 3.5 µg, respectively) into 293Tcells, and viral supernatant was harvested as described above.


Positive_regulation (transfection) of Gene_expression (transfection) of MyoD
4) Confidence 0.17 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.05 Pain Relevance 0
As observed for dys-1, the snf-6 mutation in combination with a mutation of MyoD results in muscle degeneration.
Positive_regulation (results) of Gene_expression (mutation) of MyoD in muscle
5) Confidence 0.10 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.51 Pain Relevance 0

General Comments

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