INT301743

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.09
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Musk) plasma membrane (Musk) kinase activity (Musk)
Anatomy Link Frequency
Tid1 1
Musk (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 22 96.44 Very High Very High Very High
sodium channel 3 87.68 High High
Hippocampus 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
amygdala 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Myasthenic Syndromes 88 98.44 Very High Very High Very High
Congenital Anomalies 20 79.28 Quite High
Syndrome 14 61.52 Quite High
Disease 9 58.64 Quite High
Respiratory Failure 8 56.48 Quite High
Muscle Weakness 9 49.16 Quite Low
Muscular Dystrophy 46 5.00 Very Low Very Low Very Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Myasthenia Gravis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, A727V, by virtue of being located in the catalytic loop of the enzyme, results in drastic impairment of phosphorylation and MuSK–Dok-7 interaction.
MuSK Binding (interaction) of
1) Confidence 0.41 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.31 Pain Relevance 0
Our expression studies have identified impairment of MuSK phosphorylation and MuSK–Dok-7 interaction as central to the pathogenesis of the CMS described here.
MuSK Binding (interaction) of associated with congenital myasthenic syndromes
2) Confidence 0.41 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.23 Pain Relevance 0
MuSK also binds to the short splice form of the human tumorous imaginal discs (Tid1) protein (12).
MuSK Binding (binds) of in Tid1
3) Confidence 0.35 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.32 Pain Relevance 0
MuSK phorphorylation and MuSK–Dok-7 interaction are fundamental steps of synaptic development since tyrosine autophosphorylation radically increases the catalytic activity of MuSK (21) and the recruitment of proteins containing the PTB binding domain, such as Dok-7, is essential for the downstream propagation of signaling events (33).
MuSK Binding (interaction) of
4) Confidence 0.30 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.22 Pain Relevance 0
Engagement of MuSK leads to a second messenger cascade resulting in the clustering of the AChRs, the major neurotransmitter receptors present at the NMJ.
MuSK Binding (Engagement) of associated with neurotransmitter
5) Confidence 0.17 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0 Pain Relevance 0.09

General Comments

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