INT301784

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dmd, Sntb1) cytoskeleton (Dmd, Sntb1) cytoplasm (Dmd, Sntb1)
nucleus (Dmd)
Dmd (Mus musculus)
Sntb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 44 86.64 High High
sodium channel 6 75.20 Quite High
Kinase C 8 6.32 Low Low
Hippocampus 24 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
GABAergic 16 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
amygdala 10 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 92 67.28 Quite High
Necrosis 2 66.56 Quite High
Apoptosis 8 66.04 Quite High
Stress 2 55.20 Quite High
Cognitive Disorder 24 53.16 Quite High
Targeted Disruption 30 23.64 Low Low
Lifespan 6 21.32 Low Low
Helminth Infection 14 12.40 Low Low
Congenital Anomalies 24 5.00 Very Low Very Low Very Low
Intellectual Impairment 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DystrophinÂ’s interaction with syntrophin is inhibited upon phosphorylation [88], further indicating the regulatory function that CaMKII exerts on DGC activity.
Dystrophin Binding (interaction) of syntrophin
1) Confidence 0.05 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.31 Pain Relevance 0.04
The six families of proteins encompassing the DGC can be divided into three subcomplexes: (1) a cytoplasmic complex comprised of dystrophin (or utrophin), dystrobrevin and syntrophin, (2) the transmembrane dystroglycan complex, and (3) the sarcoglycan–sarcospan complex (reviewed in [1, 18, 25, 39, 40]).
dystrophin Binding (complex) of syntrophin
2) Confidence 0.04 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.05 Pain Relevance 0.12

General Comments

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