INT301880

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (BEND5)
BEND5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arachnoid Cysts 204 99.14 Very High Very High Very High
Chromosome Aberrations 4 75.04 Quite High
Campomelic Dysplasia 16 61.68 Quite High
Cystic Kidney Diseases 4 60.68 Quite High
Cystic Lymphangioma 4 59.92 Quite High
Cyst 44 51.68 Quite High
Spina Bifida 4 29.52 Quite Low
Exencephaly /

Neural Tube Defects

8 28.12 Quite Low
Meningioma 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of ATP10D, BEND5, SHROOM3 in the qRT-PCR study correlated significantly with that of the microarray study; i.e. a low expression found in the AC by microarray was similarly low by qRT-PCR.
Gene_expression (expression) of BEND5 associated with arachnoid cysts
1) Confidence 0.60 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.45 Pain Relevance 0
For validation of the differentially expressed genes, we selected four of them for qRT-PCR: ATP10D, BEND5, SHROOM3 which were significantly altered in the ACs (p = 0.005, p = 0.008, p = 0.005, respectively), and SOX9 which showed the same trend, but did not reach significance (p = 0.08).
Gene_expression (selected) of BEND5
2) Confidence 0.52 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.56 Pain Relevance 0
The following genes differentially expressed in the SAM analysis were also analyzed with qRT-PCR to validate the microarray results: ATP10D, BEND5, SHROOM3, SOX9.
Gene_expression (expressed) of BEND5
3) Confidence 0.46 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.49 Pain Relevance 0
For all the studied genes except SOX9 (p = 0.09), the difference in expression profile between AC and arachnoid membranes was statistically significant (ATP10D: p = 0.005, BEND5: p = 0.007, SHROOM3: p = 0.005, figure 2).
Gene_expression (significant) of BEND5 associated with arachnoid cysts
4) Confidence 0.45 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.47 Pain Relevance 0

General Comments

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