INT301887

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (BEND5)
Anatomy Link Frequency
NMU 1
BEND5 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 70.84 Quite High
cva 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arachnoid Cysts 102 99.68 Very High Very High Very High
Chromosome Duplication 2 85.76 High High
Cyst 22 79.76 Quite High
Dizziness 4 71.28 Quite High
Headache 4 70.84 Quite High
Chromosome Aberrations 2 61.20 Quite High
Campomelic Dysplasia 8 59.96 Quite High
Cystic Kidney Diseases 2 58.96 Quite High
Cystic Lymphangioma 2 58.20 Quite High
Spina Bifida 2 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.
Regulation (regulated) of BEND5 in NMU associated with arachnoid cysts
1) Confidence 0.18 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.95 Pain Relevance 0.07
For validation of the differentially expressed genes, we selected four of them for qRT-PCR: ATP10D, BEND5, SHROOM3 which were significantly altered in the ACs (p = 0.005, p = 0.008, p = 0.005, respectively), and SOX9 which showed the same trend, but did not reach significance (p = 0.08).
Regulation (altered) of BEND5
2) Confidence 0.09 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.55 Pain Relevance 0

General Comments

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