INT30192

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2010
Negated 1
Speculated 2
Reported most in Title
Documents 10
Total Number 12
Disease Relevance 4.01
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
lungs 1
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Codeine 2 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
agonist 29 99.98 Very High Very High Very High
antagonist 35 99.32 Very High Very High Very High
Pain 3 99.12 Very High Very High Very High
Dopamine 5 98.76 Very High Very High Very High
Morphine 21 98.40 Very High Very High Very High
gABA 23 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 7 100.00 Very High Very High Very High
Pain 3 99.12 Very High Very High Very High
Repression 9 98.60 Very High Very High Very High
Targeted Disruption 7 97.68 Very High Very High Very High
Hypotension 3 97.44 Very High Very High Very High
Echinococcosis 8 96.96 Very High Very High Very High
Endolymphatic Hydrops 2 96.44 Very High Very High Very High
Nociception 5 94.52 High High
Pruritus 3 94.32 High High
Mydriatic 1 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice.
Regulation (Effect) of H1 associated with antinociception, analgesic and morphine
1) Confidence 0.45 Published 1985 Journal Neuropharmacology Section Title Doc Link 2858829 Disease Relevance 0 Pain Relevance 0.56
Effect of H1- and H2-receptor blockade on the inhibition of immediate cutaneous reactions.
Regulation (Effect) of H1 associated with codeine
2) Confidence 0.45 Published 1984 Journal Clin Pharm Section Title Doc Link 6141860 Disease Relevance 0.21 Pain Relevance 0.18
To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory neurones in mice.
Spec (examined) Regulation (effects) of H1 associated with qutenza and hypersensitivity
3) Confidence 0.41 Published 2008 Journal Acta Derm. Venereol. Section Abstract Doc Link 18779880 Disease Relevance 0.75 Pain Relevance 0.38
In receptor binding experiments and isolated organs medetomidine had no affinity or effects on beta 1-, beta 2-, H1, H2, 5-HT1, 5-HT2, muscarine, dopamine, tryptamine, GABA, opiate and benzodiazepine receptors.
Neg (no) Regulation (effects) of H1 associated with gaba, dopamine and opiate
4) Confidence 0.27 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2900154 Disease Relevance 0.09 Pain Relevance 0.56
The influence of the H1 and H2 receptor antagonists, terfenadine and ranitidine on the hypotensive and gastric pH effects of the histamine releasing drugs, morphine and tubocurarine.
Regulation (influence) of H1 associated with antagonist, hypotension and morphine
5) Confidence 0.27 Published 1993 Journal Anaesthesia Section Title Doc Link 8214491 Disease Relevance 0.54 Pain Relevance 0.50
To study the participation of histamine H1- and H2-receptors in pain perception, H1 and H2 receptor knockout (KO) mice were examined for pain threshold by means of three kinds of nociceptive tasks.
Regulation (participation) of H1 associated with nociception, targeted disruption, pain and pain threshold
6) Confidence 0.23 Published 2003 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14569158 Disease Relevance 0.70 Pain Relevance 0.45
In the LM layer, histamine acts on both H1 and H2 histamine receptors, and causes contraction (via H1 receptors at a low concentration) or relaxation (via H2 receptors at a high concentration in the presence of pyrilamine).
Regulation (acts) of H1
7) Confidence 0.23 Published 1997 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 9185084 Disease Relevance 0 Pain Relevance 0.05
Because of the observed sensitivity to modest changes in TetR levels, we next focused on further modifying the H1 promoter to ensure complete shRNA repression under limiting TetR levels.
Regulation (modifying) of H1 associated with repression
8) Confidence 0.09 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.44 Pain Relevance 0
It also has a partial, weak agonist effect on H1 and H2 receptors [61, 162].
Spec (partial) Regulation (effect) of H1 associated with agonist
9) Confidence 0.06 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.54 Pain Relevance 0.09
Efficacy of histamine H1 and H2 receptor blockers in the anesthetic management during operation for hydatid cysts of liver and lungs.
Regulation (Efficacy) of H1 in liver associated with anesthesia and echinococcosis
10) Confidence 0.05 Published 1988 Journal South. Med. J. Section Title Doc Link 2900555 Disease Relevance 0.26 Pain Relevance 0.10
In addition, cinnarizine and flunarizine have antihistaminic action (acting on H1 receptor) and potential (although very weak) nicotinic receptor antagonism.
Regulation (acting) of H1
11) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.20 Pain Relevance 0.33
Efficacy of histamine H1 and H2 receptor blockers in the anesthetic management during operation for hydatid cysts of liver and lungs.
Regulation (Efficacy) of H1 in lungs associated with anesthesia and echinococcosis
12) Confidence 0.02 Published 1988 Journal South. Med. J. Section Title Doc Link 2900555 Disease Relevance 0.26 Pain Relevance 0.10

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