INT30194

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Context Info
Confidence 0.08
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
DA neurons 2
striatum 2
neural 2
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 443 100.00 Very High Very High Very High
Hippocampus 21 99.84 Very High Very High Very High
Ventral tegmentum 58 98.32 Very High Very High Very High
Nucleus accumbens 69 96.20 Very High Very High Very High
imagery 5 89.60 High High
medulla 4 82.76 Quite High
Morphine 1 81.08 Quite High
Locus ceruleus 46 58.12 Quite High
Desipramine 14 55.28 Quite High
antagonist 36 46.64 Quite Low
Disease Link Frequency Relevance Heat
Depression 45 46.80 Quite Low
Psychosis 4 28.88 Quite Low
Diabetes Mellitus 6 25.00 Low Low
Amphetamine Dependence 1 25.00 Low Low
Cognitive Disorder 25 9.12 Low Low
Manic Depressive Disorder 5 5.52 Low Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis and release of DA can be further enhanced to a large extent by drugs.
Positive_regulation (enhanced) of Localization (release) of DA associated with dopamine
1) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.60
However, DA release induced by HPC stimulation has been shown to augment subsequent hippocampal-evoked neural activity of NAc neurons (Floresco, 2007; Floresco et al., 2001b).
Positive_regulation (induced) of Localization (release) of DA in neural associated with nucleus accumbens, dopamine and hippocampus
2) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.76
Finally, local infusion of insulin into the striatum of STZ-treated animals significantly recovers the ability of AMPH to stimulate DA release as measured by high-speed chronoamperometry.
Positive_regulation (recovers) of Localization (release) of DA in striatum associated with dopamine
3) Confidence 0.01 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21
However, in vivo studies have shown that a bupropion-induced sensitization is rather due to an increase in the ability of bupropion to release DA [125,126].
Positive_regulation (increase) of Localization (release) of DA associated with dopamine
4) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.71
Taken together, these data indicate that the increase in DA release is independent of the firing activity of VTA DA neurons, during not only subacute but also long-term administration of bupropion [28,29].
Positive_regulation (increase) of Localization (release) of DA in DA neurons associated with ventral tegmentum and dopamine
5) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.70

General Comments

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