INT30194

Context Info Confidence 0.08 First Reported 1985 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0 Pain Relevance 2.99

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1) cytoplasm (Ubqln1)

Anatomy Link Frequency DA neurons 2 striatum 2 neural 2 Ubqln1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 443 100.00 Hippocampus 21 99.84 Ventral tegmentum 58 98.32 Nucleus accumbens 69 96.20 imagery 5 89.60 medulla 4 82.76 Morphine 1 81.08 Locus ceruleus 46 58.12 Desipramine 14 55.28 antagonist 36 46.64

Disease Link Frequency Relevance Heat Depression 45 46.80 Psychosis 4 28.88 Diabetes Mellitus 6 25.00 Amphetamine Dependence 1 25.00 Cognitive Disorder 25 9.12 Manic Depressive Disorder 5 5.52 Urological Neuroanatomy 6 5.00 Targeted Disruption 4 5.00 Drug Dependence 2 5.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Synthesis and release of DA can be further enhanced to a large extent by drugs.

Positive_regulation (enhanced) of Localization (release) of DA associated with dopamine

1) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.60

However, DA release induced by HPC stimulation has been shown to augment subsequent hippocampal-evoked neural activity of NAc neurons (Floresco, 2007; Floresco et al., 2001b).

Positive_regulation (induced) of Localization (release) of DA in neural associated with nucleus accumbens, dopamine and hippocampus

2) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.76

Finally, local infusion of insulin into the striatum of STZ-treated animals significantly recovers the ability of AMPH to stimulate DA release as measured by high-speed chronoamperometry.

Positive_regulation (recovers) of Localization (release) of DA in striatum associated with dopamine

3) Confidence 0.01 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21

However, in vivo studies have shown that a bupropion-induced sensitization is rather due to an increase in the ability of bupropion to release DA [125,126].

Positive_regulation (increase) of Localization (release) of DA associated with dopamine

4) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.71

Taken together, these data indicate that the increase in DA release is independent of the firing activity of VTA DA neurons, during not only subacute but also long-term administration of bupropion [28,29].

Positive_regulation (increase) of Localization (release) of DA in DA neurons associated with ventral tegmentum and dopamine

5) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.70

General Comments

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