INT30195

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Context Info
Confidence 0.10
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 1.09
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
shell 2
plasma 1
neuronal 1
excitatory neurons 1
neurons 1
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1064 100.00 Very High Very High Very High
Nucleus accumbens 359 99.68 Very High Very High Very High
Hippocampus 39 99.68 Very High Very High Very High
addiction 8 98.24 Very High Very High Very High
Neurotransmitter 37 97.36 Very High Very High Very High
GABAergic 2 96.80 Very High Very High Very High
Pyramidal cell 6 94.40 High High
Desipramine 18 93.36 High High
Locus ceruleus 46 91.00 High High
Ventral tegmentum 103 90.72 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 41 99.12 Very High Very High Very High
Drug Dependence 9 98.24 Very High Very High Very High
Cognitive Disorder 76 94.28 High High
Diabetes Mellitus 18 81.04 Quite High
Stress 5 75.60 Quite High
Bordatella Infection 1 57.76 Quite High
Appetite Loss 3 55.12 Quite High
Urological Neuroanatomy 6 48.56 Quite Low
Neurodegenerative Disease 5 40.88 Quite Low
Demyelinating Disease 3 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis and release of DA can be further enhanced to a large extent by drugs.
Gene_expression (Synthesis) of DA associated with dopamine
1) Confidence 0.10 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.66
These findings suggest that DA inhibition in hypothalamic and arcuate nucleus neurons is achieved in part through the direct inhibition of excitatory neurons, probably via DA D2 receptors acting through a Gi/Go protein on K+ channels, and in part through the enhancement of GABAergic neurotransmission.
Gene_expression (acting) of DA in excitatory neurons associated with dopamine and gabaergic
2) Confidence 0.08 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307104 Disease Relevance 0.06 Pain Relevance 0.67
Mice, with a knockdown of the DA transporter and chronically elevated levels of DA, showed no deficits in acquisition of an instrumental task and responding early in training was still sensitive to tests of outcome devaluation (Yin et al. 2006).
Gene_expression (levels) of DA associated with dopamine
3) Confidence 0.03 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.48
Changes in extracellular DA levels in the NAc were compared after limited and extended training sessions, while rats lever pressed for food reward on a RI 30-s schedule.
Gene_expression (levels) of DA in lever associated with nucleus accumbens and dopamine
4) Confidence 0.03 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.20
Despite the lack of overall impairment on this task, it is clear from the correlational analysis presented in the bottom half of Figure 3 that, as in Experiment 1A, lesioned animals' ability to detect the novel object was significantly related to DA levels in the core NAc.
Gene_expression (levels) of DA associated with nucleus accumbens and dopamine
5) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.05 Pain Relevance 0.26
Analysis with partial correlations revealed that there was no significant relationship between levels of DA in the shell and the discrimination ratio (r = .04, p = .85).
Gene_expression (levels) of DA in shell associated with dopamine
6) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.07 Pain Relevance 0.22
The shell infusions produced comparable depletions in the target structure (77.8% and 69.1%), but DA levels in the adjacent core were not significantly different from shell control levels.
Gene_expression (levels) of DA in shell associated with dopamine
7) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.07 Pain Relevance 0.35
The activation of presynaptic DA autoreceptors expressed by the somatodendritic regions of DA neurons exerts a strong inhibitory effect on the neuronal activity and transmitter release of these neurons [53].
Gene_expression (expressed) of DA in neuronal associated with dopamine
8) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.84
Regulation of DAT plasma membrane expression (and subsequently of extracellular DA) by PI3K signaling is emerging as an important mechanism linking neurotransmitter transporter function to psychomotor stimulant abuse [11,13].
Gene_expression (expression) of DA in plasma associated with neurotransmitter and dopamine
9) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.30 Pain Relevance 0.35
Indeed, insulin signaling increases DA uptake capacity and cell surface expression [11,13].
Gene_expression (expression) of DA associated with dopamine
10) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.12 Pain Relevance 0.30
PI3K signaling, which is stimulated by activation of IRs and other RTKs [23], plays a critical role in the maintenance of DA clearance and DAT cell surface expression [11,13,21,35].
Gene_expression (expression) of DA associated with dopamine
11) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.37
In the G8 generation, 12 rats from each parental strain and 126 male rats were used and in the G10 generation, 12 DA rats and 11 PVGav1 parental rats and 186 male rats.
Gene_expression (generation) of DA associated with sprains and strains
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691596 Disease Relevance 0.26 Pain Relevance 0
To understand better the physiological importance of these effects, the possibility that the NE neurons themselves could be the main source of DA in the hippocampus was addressed.
Gene_expression (source) of DA in neurons associated with dopamine and hippocampus
13) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.93
When moderate doses of atomoxetine and methylphenidate, which increase endogenous NE and DA levels in PFC [81,82] were administered, there was an improvement of PFC function via actions on ?
Gene_expression (levels) of DA associated with dopamine
14) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.17 Pain Relevance 0.26

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