INT30196

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Context Info
Confidence 0.08
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.29
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
neuronal 2
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 270 100.00 Very High Very High Very High
Nucleus accumbens 41 89.96 High High
agonist 9 89.08 High High
Ventral tegmentum 67 89.00 High High
Central nervous system 5 81.72 Quite High
Morphine 1 81.64 Quite High
Eae 15 76.04 Quite High
Pyramidal cell 3 54.16 Quite High
antagonist 19 51.60 Quite High
antidepressant 17 39.28 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 6 95.36 Very High Very High Very High
Stress 1 76.68 Quite High
Diabetes Mellitus 6 64.12 Quite High
Appetite Loss 1 53.52 Quite High
Drug Dependence 5 27.08 Quite Low
Affective Disorder 1 25.12 Quite Low
Depression 23 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 14 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis and release of DA can be further enhanced to a large extent by drugs.
Positive_regulation (enhanced) of Gene_expression (Synthesis) of DA associated with dopamine
1) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.66
The activation of presynaptic DA autoreceptors expressed by the somatodendritic regions of DA neurons exerts a strong inhibitory effect on the neuronal activity and transmitter release of these neurons [53].
Positive_regulation (activation) of Gene_expression (expressed) of DA in neuronal associated with dopamine
2) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.85
Indeed, insulin signaling increases DA uptake capacity and cell surface expression [11,13].
Positive_regulation (increases) of Gene_expression (expression) of DA associated with dopamine
3) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.12 Pain Relevance 0.30
When moderate doses of atomoxetine and methylphenidate, which increase endogenous NE and DA levels in PFC [81,82] were administered, there was an improvement of PFC function via actions on ?
Positive_regulation (increase) of Gene_expression (levels) of DA associated with dopamine
4) Confidence 0.01 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.17 Pain Relevance 0.26

General Comments

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