INT30197

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Context Info
Confidence 0.08
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 2.07
Pain Relevance 18.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
NAcs 2
5-HT neurons 2
DA neurons 1
brain 1
BLA 1
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1877 100.00 Very High Very High Very High
Nucleus accumbens 626 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Morphine 21 99.98 Very High Very High Very High
Ventral tegmentum 420 99.36 Very High Very High Very High
amygdala 18 96.56 Very High Very High Very High
Catecholamine 65 95.88 Very High Very High Very High
Neurotransmitter 55 95.88 Very High Very High Very High
antagonist 135 95.68 Very High Very High Very High
agonist 63 94.40 High High
Disease Link Frequency Relevance Heat
Stress 21 99.48 Very High Very High Very High
Cognitive Disorder 106 95.36 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 80 94.04 High High
Manic Depressive Disorder 16 72.20 Quite High
Depression 156 62.88 Quite High
Opiate Addiction 2 57.12 Quite High
Apoptosis 2 49.44 Quite Low
Drug Dependence 22 46.16 Quite Low
Diabetes Mellitus 12 42.16 Quite Low
Psychosis 14 40.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In striata ipsilateral to the lesion, the DOPA/DA ratio was elevated 4-fold, and the DOPA/DA and HVA/DA ratios were elevated 2-fold as compared to values in contralateral striata.
Positive_regulation (elevated) of DA associated with dopamine
1) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.66
Morphine (20 mg/kg, 30 min) and haloperidol (2.5 mg/kg, 60 min), i.e. drugs known to accelerate the turnover and release of DA, further elevated the DOPAC/DA and HVA/DA ratios in lesioned striata to levels approx. 5 times higher than the ratios measured on contralateral sides of saline-treated controls.
Positive_regulation (elevated) of DA associated with dopamine and morphine
2) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.74
In striata ipsilateral to the lesion, the DOPA/DA ratio was elevated 4-fold, and the DOPA/DA and HVA/DA ratios were elevated 2-fold as compared to values in contralateral striata.
Positive_regulation (elevated) of DA associated with dopamine
3) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.67
Administration of gamma-butyrolacetone (750 mg/kg, 30 min), i.e. of a drug which accelerates synthesis of DA, further increased the DOPA/DA ratio in lesioned striata to levels 37 times higher than those measured on the control side of saline-injected controls.
Positive_regulation (increased) of DA associated with dopamine
4) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.74
Morphine (20 mg/kg, 30 min) and haloperidol (2.5 mg/kg, 60 min), i.e. drugs known to accelerate the turnover and release of DA, further elevated the DOPAC/DA and HVA/DA ratios in lesioned striata to levels approx. 5 times higher than the ratios measured on contralateral sides of saline-treated controls.
Positive_regulation (elevated) of DA associated with dopamine and morphine
5) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.74
In striata ipsilateral to the lesion, the DOPA/DA ratio was elevated 4-fold, and the DOPA/DA and HVA/DA ratios were elevated 2-fold as compared to values in contralateral striata.
Positive_regulation (elevated) of DA associated with dopamine
6) Confidence 0.08 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.67
Here, we test (1) the necessity of CORT during inescapable stress (IS) and/or morphine for IS potentiation of morphine-induced NAcs DA and (2) the sufficiency of enhanced CORT, in the absence of prior IS, to potentiate morphine-induced NAcs DA as well as morphine conditioned place preference (CPP) in male Sprague-Dawley rats.
Positive_regulation (induced) of NAcs DA in NAcs associated with stress, dopamine and morphine
7) Confidence 0.03 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.70 Pain Relevance 1.13
This study also tested the hypothesis that increase in NAc DA activity is correlated with instrumental responding during extinction maintained by a conditioned stimulus paired with food.


Positive_regulation (increase) of DA in NAc associated with nucleus accumbens and dopamine
8) Confidence 0.02 Published 2006 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.66
Consistent with the importance of conditional stimuli (CS+) in the initiation of approach behavior, visual and olfactory stimuli associated with natural rewards such as food or sexually receptive conspecifics can evoke significant increases in DA efflux in the NAc that precede similar changes observed during consummatory behavior (Fiorino et al. 1997; Ahn and Phillips 1999, 2002).
Positive_regulation (increases) of DA in olfactory associated with nucleus accumbens and dopamine
9) Confidence 0.02 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.42
DA efflux was also significantly elevated during responding in extinction only on day 16.


Positive_regulation (elevated) of DA associated with dopamine
10) Confidence 0.02 Published 2006 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.53
Recent work has demonstrated that DA and glutamate receptor activation within NAc is required for the consolidation of spatial memory, suggesting a modulatory role of these neurotransmitter systems in the intracellular mechanisms posited to be involved in long-term plasticity (e.g., Ferretti et al., 2005; Ferretti, Sargolini, Oliverio, Mele, & Roullet, 2007; Mele et al., 2004).
Positive_regulation (activation) of DA associated with nucleus accumbens, neurotransmitter, dopamine and glutamate receptor
11) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.27 Pain Relevance 0.75
Increased extracellular DA concentration also activates postsynaptic DA receptors and thereby enhances the motor-activating effects [53], as observed in the behavioral dose-response of MPD (Fig. 1).
Positive_regulation (activates) of DA associated with dopamine
12) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 1.04
The demonstration that activation of DA can potentiate or attenuate the responsiveness of NAc neurons to HPC and basolateral amygdala (BLA) evoked firing may underlie these effects (Charara & Grace, 2003; Floresco, Blaha, Yang, & Phillips, 2001a, 2001b).
Positive_regulation (activation) of DA in BLA associated with nucleus accumbens, dopamine and amygdala
13) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.29 Pain Relevance 0.46
Consistent with this suggestion, stimulation of hippocampal inputs to the NAc has been shown to increase DA efflux in the NAc (e.g., Floresco et al., 2001b; Legault, Rompre, & Wise, 2000) and in particular within the NAc shell (Peleg-Raibstein & Feldon, 2006).
Positive_regulation (increase) of DA in shell associated with nucleus accumbens and dopamine
14) Confidence 0.02 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.73
Increased extracellular DA concentration also activates postsynaptic DA receptors and thereby enhances the motor-activating effects [53], as observed in the behavioral dose-response of MPD (Fig. 1).
Positive_regulation (Increased) of DA associated with dopamine
15) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 1.07
The activation of presynaptic DA autoreceptors expressed by the somatodendritic regions of DA neurons exerts a strong inhibitory effect on the neuronal activity and transmitter release of these neurons [53].
Positive_regulation (activation) of DA in neuronal associated with dopamine
16) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.79
Thus, increased extracellular DA level produces inhibition of the firing of DA neurons [54-57] and may result in further attenuation from baseline of P2, N2, and P3 components of VTA, NAc, and PFC neurons as the MPD dosage increased in the present study.
Positive_regulation (increased) of DA in neurons associated with nucleus accumbens, ventral tegmentum and dopamine
17) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.89
The drug has been shown to block the dopamine transporter (DAT) and thereby elevates extracellular dopamine (DA) levels in the ventral tegmental area (VTA), nucleus accumbens (NAc), and prefrontal cortex (PFC), which are brain areas of the mesocorticolimbic DA system involved in the locomotor and reinforcing effects of psychostimulants and other drugs of abuse [7-13].
Positive_regulation (elevates) of DA in prefrontal associated with nucleus accumbens, ventral tegmentum and dopamine
18) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0.28 Pain Relevance 0.65
Methylphenidate binds to DAT at the presynaptic region of these brain areas and blocks their DA re-uptake, resulting in accumulation of extracellular DA [52].
Positive_regulation (accumulation) of DA in brain associated with dopamine
19) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0.05 Pain Relevance 0.78
As substrates, AMPHs not only competitively inhibit DA reuptake and thereby increase synaptic DA, but also promote reversal of transport, resulting in efflux of DA via the DAT [6].
Positive_regulation (increase) of DA associated with dopamine
20) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.06 Pain Relevance 0.65

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