INT301995

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.80
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
intestine 1
kidney 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 36 99.34 Very High Very High Very High
cytokine 9 73.48 Quite High
chemokine 1 50.08 Quite High
Inflammation 4 43.84 Quite Low
alcohol 3 43.32 Quite Low
imagery 17 32.40 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 59 99.34 Very High Very High Very High
Shock 1 99.04 Very High Very High Very High
Familial Adenomatous Polyposis 4 98.96 Very High Very High Very High
Infection 109 98.40 Very High Very High Very High
Cancer 132 97.64 Very High Very High Very High
Peritonitis 4 91.20 High High
Adhesions 23 85.20 High High
Malignant Neoplastic Disease 15 83.00 Quite High
Apoptosis 53 75.88 Quite High
Papillomavirus Infection 19 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-defensins has been described in ileal Crohn's disease [52] and expression analyses in human Crohn's disease biopsies have demonstrated down-regulation of E-cadherin [8]–[10].
Spec (analyses) Regulation (regulation) of E-cadherin associated with crohn's disease and disease
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.61 Pain Relevance 0.23
Down-regulation of E-cadherin is associated with the pathogenesis of infections with enteropathogenic bacteria and Crohn's disease.


Regulation (regulation) of E-cadherin associated with crohn's disease, disease and infection
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.39 Pain Relevance 0.05
Tight junctions also appeared unchanged in Cre+Cdh1fl/fl mice treated with tamoxifen for 3 days.
Neg (unchanged) Spec (appeared) Regulation (unchanged) of Cdh1fl
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.42 Pain Relevance 0
To date E-cadherin has not been directly targeted in the mouse intestine to clarify its role in this tissue.
Neg (not) Regulation (targeted) of E-cadherin in intestine
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.87 Pain Relevance 0.11
To determine whether the molecular alterations of EMT occurred in these cells, we examined the localization of several adherent junction proteins, such as E-cadherin and ZO-1, by confocal immunofluorescence staining.
Spec (examined) Regulation (localization) of E-cadherin
5) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.24 Pain Relevance 0
This further supports the notion that Lm subverts junction disassembly since both Lm invasion via E-cadherin and junction regulation via E-cadherin endocytosis require functional dynamin [102], [129].
Regulation (regulation) of E-cadherin
6) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.16 Pain Relevance 0
Consistent with these findings, protein levels of YAP downstream targets, E-cadherin and survivin did not change significantly in Irs2-/- kidney (data not shown).
Regulation (targets) of E-cadherin in kidney
7) Confidence 0.08 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.12 Pain Relevance 0
This further supports the notion that Lm subverts junction disassembly since both Lm invasion via E-cadherin and junction regulation via E-cadherin endocytosis require functional dynamin [102], [129].
Regulation (regulation) of E-cadherin
8) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.17 Pain Relevance 0
In addition, specific up-regulated genes including CD24, E-cadherin, FABP5, keratins, heat shock protein (27 kDa), and others identified by microarray analysis were also identified by flow cytometry and immunostaining.
Regulation (regulated) of E-cadherin associated with shock
9) Confidence 0.04 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.83 Pain Relevance 0.09

General Comments

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