INT30202

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.04
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRL) extracellular region (GHRL) cytoplasm (GHRL)
Anatomy Link Frequency
plasma 2
substantia nigra 1
duodenum 1
globus pallidus 1
caudate-putamen 1
GHRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 12 100.00 Very High Very High Very High
Substantia nigra 9 98.00 Very High Very High Very High
Enkephalin 12 94.24 High High
Inflammation 45 93.96 High High
abdominal pain 1 79.88 Quite High
Opioid 3 74.40 Quite High
nud 6 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 51 100.00 Very High Very High Very High
Celiac Disease 7 99.50 Very High Very High Very High
INFLAMMATION 45 93.96 High High
Abdominal Pain 1 79.88 Quite High
Anaemia 1 79.16 Quite High
Gastritis 18 75.00 Quite High
Necrosis 3 74.24 Quite High
Cancer 9 73.88 Quite High
Body Weight 6 71.08 Quite High
Frailty 7 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the duodenum of CD children, the number of ghrelin-positive cells is increased compared with the control patients.
Positive_regulation (increased) of ghrelin in duodenum associated with celiac disease
1) Confidence 0.44 Published 2010 Journal J. Endocrinol. Invest. Section Abstract Doc Link 19794298 Disease Relevance 1.01 Pain Relevance 0.08
The treatment group showed a marginal increase (P=0.060) in plasma ghrelin/obestatin ratio.
Positive_regulation (increase) of obestatin in plasma
2) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2811295 Disease Relevance 0.37 Pain Relevance 0.05
A recent study has linked obestatin to obesity in humans, showing that fasting plasma obestatin was significantly suppressed in obese subjects (15, 16) and increased as weight was lost.
Positive_regulation (increased) of obestatin in plasma associated with obesity
3) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.88 Pain Relevance 0.03
Guo et al. (15) suggested that the circulating preprandial ghrelin-to-obestatin ratio is elevated in obese humans.
Positive_regulation (elevated) of obestatin associated with obesity
4) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.78 Pain Relevance 0.03
Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra.
Positive_regulation (increases) of dynorphin-related peptide in globus pallidus associated with dynorphin and substantia nigra
5) Confidence 0.01 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859094 Disease Relevance 0 Pain Relevance 0.68
Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra.
Positive_regulation (increases) of dynorphin-related peptide in caudate-putamen associated with dynorphin and substantia nigra
6) Confidence 0.00 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859094 Disease Relevance 0 Pain Relevance 0.68
Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra.
Positive_regulation (increases) of dynorphin-related peptide in substantia nigra associated with dynorphin and substantia nigra
7) Confidence 0.00 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859094 Disease Relevance 0 Pain Relevance 0.68

General Comments

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