INT302038

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.12
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp2) cell adhesion (Nrp2) plasma membrane (Nrp2)
Anatomy Link Frequency
sensory neurons 4
Nrp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 65.12 Quite High
Spinal cord 12 5.00 Very Low Very Low Very Low
Versed 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 96.80 Very High Very High Very High
Injury 18 87.60 High High
Adhesions 4 80.68 Quite High
Toxicity 22 76.80 Quite High
INFLAMMATION 24 65.12 Quite High
Infection 10 6.36 Low Low
Cataract 4 5.92 Low Low
Hyphema 4 5.52 Low Low
Organ Transplantation 24 5.00 Very Low Very Low Very Low
Cancer 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrastromal delivery of NP2-targeting amiRNA inhibits corneal lymphangiogenesis
Positive_regulation (delivery) of Gene_expression (delivery) of NP2
1) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.15 Pain Relevance 0
These data confirmed that the intrastromal delivery of NP2-amiR resulted in reduced NP2 expression.


Positive_regulation (resulted) of Gene_expression (expression) of NP2
2) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.14 Pain Relevance 0
Intrastromal delivery of NP2-targeting amiRNA has no effect on cell infiltration
Positive_regulation (delivery) of Gene_expression (delivery) of NP2
3) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.30 Pain Relevance 0.03
NP2-targeting amiRNA suppresses VEGF-C-induced NP2 expression in mouse LECs
Positive_regulation (induced) of Gene_expression (expression) of NP2
4) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0 Pain Relevance 0
In vivo, AAV5 mediated expression of the most effective Npn-2 shRNA resulted in knockdown of Npn-2 in DRG sensory neurons.
Positive_regulation (mediated) of Gene_expression (expression) of Npn-2 in sensory neurons
5) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.26 Pain Relevance 0
In vivo, AAV5 mediated expression of the most effective Npn-2 shRNA resulted in knockdown of Npn-2 in DRG sensory neurons.
Positive_regulation (resulted) of Gene_expression (expression) of Npn-2 in sensory neurons
6) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.26 Pain Relevance 0

General Comments

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