INT302039

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 1.65
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp2) cell adhesion (Nrp2) plasma membrane (Nrp2)
Anatomy Link Frequency
sensory neurons 1
red nucleus 1
neurons 1
dendritic cell 1
dorsal root ganglia 1
Nrp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 30 89.44 High High
Inflammation 24 86.84 High High
anesthesia 9 49.92 Quite Low
Versed 20 40.32 Quite Low
imagery 5 28.16 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 94.16 High High
Spinal Cord Injury 10 88.16 High High
INFLAMMATION 24 86.84 High High
Cytomegalovirus Infection 20 82.80 Quite High
Injury 27 81.84 Quite High
Toxicity 55 79.28 Quite High
Organ Transplantation 24 78.48 Quite High
Wound Healing 4 71.60 Quite High
Disease 16 59.84 Quite High
Cancer 20 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we speculate that loss of NP2 promotes allograft survival at least in part by inhibiting dendritic cell trafficking through VEGFR-3-mediated signaling.
Negative_regulation (loss) of NP2 in dendritic cell
1) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.43 Pain Relevance 0
In addition, our data showed that selective inhibition of lymphangiogenesis on vascularized recipient beds before transplantation by blockade of NP2 led to significantly improved graft survival.
Negative_regulation (blockade) of NP2
2) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0 Pain Relevance 0
More importantly, our results indicate that inhibition of NP2 provides novel treatment options for disorders associated with pathological lymphangiogenesis without causing the corresponding complications induced by anti-hemangiogenic effect.
Negative_regulation (inhibition) of NP2
3) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.17 Pain Relevance 0.03
The fact that afferent corneal lymphatics plays a crucial role in allograft rejection [8], together with our data that blockade of NP2 selectively inhibited corneal lymphangiogenesis, prompted us to investigate whether knockdown of NP2 could improve corneal allograft survival.
Negative_regulation (blockade) of NP2
4) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.28 Pain Relevance 0.04
In vivo, AAV5 mediated expression of the most effective Npn-2 shRNA resulted in knockdown of Npn-2 in DRG sensory neurons.
Negative_regulation (knockdown) of Npn-2 in sensory neurons
5) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.25 Pain Relevance 0
Axon outgrowth is considerably improved when neurons are cultured on Semaphorin3A (Sema3A)-deficient meningeal cells [16] and axon crossing from an astrocyte to a meningeal cell substrate is enhanced by blocking Npn-2 [17].
Negative_regulation (blocking) of Npn-2 in neurons
6) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.29 Pain Relevance 0.12
AAV mediated knockdown of Npn-2 in the red nucleus
Negative_regulation (knockdown) of Npn-2 in red nucleus
7) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.23 Pain Relevance 0
AAV5 mediated knockdown of Npn-2 in rat dorsal root ganglia
Negative_regulation (knockdown) of Npn-2 in dorsal root ganglia
8) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0 Pain Relevance 0
However, after injection of AAV2 expressing Npn-2 shRNAs, no knockdown was observed under these conditions (not shown).


Negative_regulation (injection) of Npn-2
9) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0 Pain Relevance 0

General Comments

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