INT302043

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 1.53
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp2) cell adhesion (Nrp2) plasma membrane (Nrp2)
Anatomy Link Frequency
lymph nodes 2
endothelial cells 2
corneas 2
F11 2
Nrp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 73.28 Quite High
Spinal cord 24 5.00 Very Low Very Low Very Low
Versed 16 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 30 97.88 Very High Very High Very High
Toxicity 44 96.40 Very High Very High Very High
Targeted Disruption 24 95.20 Very High Very High Very High
Corneal Neovascularization 18 78.80 Quite High
Organ Transplantation 36 78.24 Quite High
Adhesions 6 76.88 Quite High
Neuroblastoma 4 76.60 Quite High
INFLAMMATION 36 73.28 Quite High
Disease 24 67.68 Quite High
Aids-related Complex 12 60.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data confirmed that the intrastromal delivery of NP2-amiR resulted in reduced NP2 expression.


Negative_regulation (reduced) of Gene_expression (expression) of NP2
1) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.14 Pain Relevance 0
To determine the effect of reduced NP2 expression on cell infiltration associated with corneal suture injury in recipient beds immediately before transplantation, we next examined CD11 antigen-like family member B (CD11b)-positive macrophage infiltration into inflamed corneas in mice treated with NP2-amiR.
Negative_regulation (reduced) of Gene_expression (expression) of NP2 in corneas associated with injury
2) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.32 Pain Relevance 0.04
These data demonstrate that decreasing NP2 expression has no direct effect on corneal macrophages trafficking to regional lymph nodes, and further confirm the selective effect of NP2 knockdown in the inflamed cornea.
Negative_regulation (decreasing) of Gene_expression (expression) of NP2 in lymph nodes
3) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.33 Pain Relevance 0.03
VEGF-C-induced NP2 expression at both mRNA and protein levels was significantly suppressed by NP2 amiRNA in mouse lymphatic endothelial cells.
Negative_regulation (suppressed) of Gene_expression (expression) of NP2 in endothelial cells
4) Confidence 0.43 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994732 Disease Relevance 0.13 Pain Relevance 0.03
Determination of NP2 levels by ELISA
Negative_regulation (Determination) of Gene_expression (levels) of NP2
5) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0 Pain Relevance 0
Intrastromal delivery of NP2-targeting amiRNA suppresses corneal NP2 expression
Negative_regulation (suppresses) of Gene_expression (expression) of NP2
6) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0 Pain Relevance 0
Two out of seven Npn-2 shRNA sequences successfully reduced Npn-2 mRNA expression to 7.8 ± 1.1% and 13.3 ± 1.0% respectively (Figure 2c).


Negative_regulation (reduced) of Gene_expression (expression) of Npn-2 mRNA
7) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.08 Pain Relevance 0
Substantial in vivo reduction of Npn-2 expression was achieved by injection of AAV5-shRNA in the DRG, without clear indication of cellular toxicity.
Negative_regulation (reduction) of Gene_expression (expression) of Npn-2 associated with toxicity
8) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.48 Pain Relevance 0
However, after injection of AAV2 expressing Npn-2 shRNAs, no knockdown was observed under these conditions (not shown).


Negative_regulation (injection) of Gene_expression (expressing) of Npn-2
9) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0 Pain Relevance 0
We initially developed two shRNAs for Npn-1 and seven for Npn-2 and evaluated their capacity to silence Npn-1 or Npn-2 expression in F11 cells.
Negative_regulation (silence) of Gene_expression (expression) of Npn-2 in F11
10) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.05 Pain Relevance 0

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